https://scholars.lib.ntu.edu.tw/handle/123456789/144277
標題: | Asperjinone, a Nor-Neolignan, and Terrein, a Suppressor of ABCG2-Expressing Breast Cancer Cells, from Thermophilic Aspergillus terreus | 作者: | Liao, Wen-Ying Shen, Chia-Ning Lin, Li-Hua Yang, Yu-Liang Han, Hsin-Ying Chen, Jing-Wei Kuo, Sheng-Chu Wu, Shih-Hsiung Liaw, Chih-Chuang |
公開日期: | 2012 | 卷: | 75 | 期: | 4 | 起(迄)頁: | 630-635 | 來源出版物: | JOURNAL OF NATURAL PRODUCTS | 摘要: | Breast cancer cells express ABCG2 transporters, which mediate multidrug resistance. Discovering a novel compound that can suppress ABCG2 expression and restore drug sensitivity could be the key to improving breast cancer therapeutics. In the current work, one new nor-neolignan, asperjinone (1), as well as 12 other known compounds, was isolated from Aspergillus terreus. The structure of the new isolate was determined by spectroscopic methods. Among these isolates, terrein (2) displayed strong cytotoxicity against breast cancer MCF-7 cells. Treatment with terrein (2) significantly suppressed growth of ABCG2-expressing breast cancer cells. This suppressive effect was achieved by inducing apoptosis via activating the caspase-7 pathway and inhibiting the Akt signaling pathway, which led to a decrease in ABCG2-expressing cells and a reduction in the side-population phenotype. ? 2012 The American Chemical Society and American Society of Pharmacognosy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/243320 | DOI: | 10.1021/np200866z | SDG/關鍵字: | asperjinone; breast cancer resistance protein; caspase 7; neolignan; paclitaxel; plant medicinal product; protein kinase B; terrein; unclassified drug; verapamil; antineoplastic activity; apoptosis; article; Aspergillus terreus; breast cancer; cancer cell; carbon nuclear magnetic resonance; cell growth; cell proliferation; cell strain MCF 7; controlled study; cytotoxicity; drug potency; drug structure; fungus isolation; gene expression; growth inhibition; human; human cell; phenotype; proton nuclear magnetic resonance; signal transduction; tumor suppressor gene; Antineoplastic Agents; Aspergillus; ATP-Binding Cassette Transporters; Breast Neoplasms; Caspase 7; Cyclopentanes; Drug Screening Assays, Antitumor; Female; Humans; Lignans; Molecular Structure; Neoplasm Proteins; Nuclear Magnetic Resonance, Biomolecular; Proto-Oncogene Proteins c-akt; Taiwan; Aspergillus terreus |
顯示於: | 生化科學研究所 |
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