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  4. Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells
 
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Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells

Resource
JOURNAL OF CELLULAR PHYSIOLOGY, 226(9), 2338-2349
Journal
Journal of Cellular Physiology
Pages
2338-2349
Date Issued
2011
Date
2011
Author(s)
Li, Chia-Yang
Chao, Louis Kuoping
Wang, Shu-Chi
Chang, Hon-Zu
Tsai, Min-Lung
Fang, Shih-Hua
Liao, Pei-Chun
Ho, Chen-Lung
Chen, Shui-Tein
Cheng, Wei-Chung
Chiang, Chi-Shiun
Kuo, Yueh-Hsiung
Hua, Kuo-Feng
Hsu, Ian C.
DOI
10.1002/jcp.22576
URI
http://ntur.lib.ntu.edu.tw//handle/246246/243354
Abstract
Honokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti-inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)-stimulated human monocyte-derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS-induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS-activated DCs, (2) reducing the production of TNF-α, IL-1β, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-β1 by LPS-activated DCs, (3) inhibiting the LPS-induced DC-elicited allogeneic T-cell proliferation, and (4) shifting the LPS-induced DC-driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKKα, and IκBα in LPS-activated DCs. Collectively, the findings show that the anti-inflammatory actions of HNK on LPS-induced DCs are associated with the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways. ? 2010 Wiley-Liss, Inc.
SDGs

[SDGs]SDG3

Other Subjects
B7 antigen; CD40 antigen; CD83 antigen; CD86 antigen; gamma interferon; glycoprotein p 15095; honokiol; I kappa B alpha; I kappa B kinase alpha; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12p70; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; lipopolysaccharide; major histocompatibility antigen class 2; mitogen activated protein kinase; mitogen activated protein kinase 3; synaptophysin; transforming growth factor beta activated kinase 1; tumor necrosis factor alpha; article; cell culture; cell maturation; cell proliferation; cell viability; dendritic cell; enzyme repression; inflammation; monocyte derived dendritic cell; priority journal; protein expression; signal transduction; T lymphocyte; Th1 cell; Th2 cell; Biphenyl Compounds; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dendritic Cells; Endocytosis; Enzyme Activation; Humans; Inflammation; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phenotype; Th1 Cells; Th2 Cells; Magnolia officinalis
Type
journal article
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