https://scholars.lib.ntu.edu.tw/handle/123456789/144311
標題: | Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells | 作者: | Li, Chia-Yang Chao, Louis Kuoping Wang, Shu-Chi Chang, Hon-Zu Tsai, Min-Lung Fang, Shih-Hua Liao, Pei-Chun Ho, Chen-Lung Chen, Shui-Tein Cheng, Wei-Chung Chiang, Chi-Shiun Kuo, Yueh-Hsiung Hua, Kuo-Feng Hsu, Ian C. |
公開日期: | 2011 | 起(迄)頁: | 2338-2349 | 來源出版物: | Journal of Cellular Physiology | 摘要: | Honokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti-inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)-stimulated human monocyte-derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS-induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS-activated DCs, (2) reducing the production of TNF-α, IL-1β, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-β1 by LPS-activated DCs, (3) inhibiting the LPS-induced DC-elicited allogeneic T-cell proliferation, and (4) shifting the LPS-induced DC-driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKKα, and IκBα in LPS-activated DCs. Collectively, the findings show that the anti-inflammatory actions of HNK on LPS-induced DCs are associated with the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways. ? 2010 Wiley-Liss, Inc. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/243354 | DOI: | 10.1002/jcp.22576 | SDG/關鍵字: | B7 antigen; CD40 antigen; CD83 antigen; CD86 antigen; gamma interferon; glycoprotein p 15095; honokiol; I kappa B alpha; I kappa B kinase alpha; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12p70; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; lipopolysaccharide; major histocompatibility antigen class 2; mitogen activated protein kinase; mitogen activated protein kinase 3; synaptophysin; transforming growth factor beta activated kinase 1; tumor necrosis factor alpha; article; cell culture; cell maturation; cell proliferation; cell viability; dendritic cell; enzyme repression; inflammation; monocyte derived dendritic cell; priority journal; protein expression; signal transduction; T lymphocyte; Th1 cell; Th2 cell; Biphenyl Compounds; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dendritic Cells; Endocytosis; Enzyme Activation; Humans; Inflammation; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phenotype; Th1 Cells; Th2 Cells; Magnolia officinalis |
顯示於: | 生化科學研究所 |
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