https://scholars.lib.ntu.edu.tw/handle/123456789/144311
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Li, Chia-Yang | en |
dc.contributor.author | Chao, Louis Kuoping | en |
dc.contributor.author | Wang, Shu-Chi | en |
dc.contributor.author | Chang, Hon-Zu | en |
dc.contributor.author | Tsai, Min-Lung | en |
dc.contributor.author | Fang, Shih-Hua | en |
dc.contributor.author | Liao, Pei-Chun | en |
dc.contributor.author | Ho, Chen-Lung | en |
dc.contributor.author | Chen, Shui-Tein | en |
dc.contributor.author | Cheng, Wei-Chung | en |
dc.contributor.author | Chiang, Chi-Shiun | en |
dc.contributor.author | Kuo, Yueh-Hsiung | en |
dc.contributor.author | Hua, Kuo-Feng | en |
dc.contributor.author | Hsu, Ian C. | en |
dc.creator | Li, Chia-Yang;Chao, Louis Kuoping;Wang, Shu-Chi;Chang, Hon-Zu;Tsai, Min-Lung;Fang, Shih-Hua;Liao, Pei-Chun;Ho, Chen-Lung;Chen, Shui-Tein;Cheng, Wei-Chung;Chiang, Chi-Shiun;Kuo, Yueh-Hsiung;Hua, Kuo-Feng;Hsu, Ian C. | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-10-20T06:15:45Z | - |
dc.date.accessioned | 2018-07-06T06:38:09Z | - |
dc.date.available | 2012-10-20T06:15:45Z | - |
dc.date.available | 2018-07-06T06:38:09Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/243354 | - |
dc.description.abstract | Honokiol (HNK) is a phenolic compound isolated from the bark of houpu (Magnolia officinalis), a plant widely used in traditional Chinese and Japanese medicine. While substantial evidence indicates that HNK possesses anti-inflammatory activity, its effect on dendritic cells (DCs) during the inflammatory reaction remains unclear. The present study investigates how HNK affects lipopolysaccharide (LPS)-stimulated human monocyte-derived DCs. Our experimental results show that HNK inhibits the inflammatory response of LPS-induced DCs by (1) suppressing the expression of CD11c, CD40, CD80, CD83, CD86, and MHC-II on LPS-activated DCs, (2) reducing the production of TNF-α, IL-1β, IL-6, and IL-12p70 but increasing the production of IL-10 and TGF-β1 by LPS-activated DCs, (3) inhibiting the LPS-induced DC-elicited allogeneic T-cell proliferation, and (4) shifting the LPS-induced DC-driven Th1 response toward a Th2 response. Further, our results show that HNK inhibits the phosphorylation levels of ERK1/2, p38, JNK1/2, IKKα, and IκBα in LPS-activated DCs. Collectively, the findings show that the anti-inflammatory actions of HNK on LPS-induced DCs are associated with the NF-κB and mitogen-activated protein kinase (MAPK) signaling pathways. ? 2010 Wiley-Liss, Inc. | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF CELLULAR PHYSIOLOGY, 226(9), 2338-2349 | en |
dc.relation.ispartof | Journal of Cellular Physiology | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | B7 antigen; CD40 antigen; CD83 antigen; CD86 antigen; gamma interferon; glycoprotein p 15095; honokiol; I kappa B alpha; I kappa B kinase alpha; immunoglobulin enhancer binding protein; interleukin 10; interleukin 12p70; interleukin 13; interleukin 1beta; interleukin 4; interleukin 6; lipopolysaccharide; major histocompatibility antigen class 2; mitogen activated protein kinase; mitogen activated protein kinase 3; synaptophysin; transforming growth factor beta activated kinase 1; tumor necrosis factor alpha; article; cell culture; cell maturation; cell proliferation; cell viability; dendritic cell; enzyme repression; inflammation; monocyte derived dendritic cell; priority journal; protein expression; signal transduction; T lymphocyte; Th1 cell; Th2 cell; Biphenyl Compounds; Cell Differentiation; Cell Line; Cell Proliferation; Cell Survival; Cytokines; Dendritic Cells; Endocytosis; Enzyme Activation; Humans; Inflammation; Lignans; Lipopolysaccharides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Monocytes; NF-kappa B; Phenotype; Th1 Cells; Th2 Cells; Magnolia officinalis | - |
dc.title | Honokiol Inhibits LPS-Induced Maturation and Inflammatory Response of Human Monocyte-Derived Dendritic Cells | en |
dc.type | journal article | en |
dc.identifier.doi | 10.1002/jcp.22576 | en |
dc.relation.pages | 2338-2349 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/243354/-1/57.pdf | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | with fulltext | - |
顯示於: | 生化科學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。