https://scholars.lib.ntu.edu.tw/handle/123456789/144341
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lin, Hsiu-Hsia | en |
dc.contributor.author | Liao, Chi-Jr | en |
dc.contributor.author | Lee, Ying-Chu | en |
dc.contributor.author | Hu, Keng-Hsun | en |
dc.contributor.author | Meng, Hsien-Wei | en |
dc.contributor.author | Chu, Sin-Tak | en |
dc.creator | Lin, Hsiu-Hsia;Liao, Chi-Jr;Lee, Ying-Chu;Hu, Keng-Hsun;Meng, Hsien-Wei;Chu, Sin-Tak | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-10-20T06:21:18Z | - |
dc.date.accessioned | 2018-07-06T06:39:16Z | - |
dc.date.available | 2012-10-20T06:21:18Z | - |
dc.date.available | 2018-07-06T06:39:16Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/243416 | - |
dc.description.abstract | Lipocalin-2 (Lcn-2) is an acute-phase protein that has been implicated in diverse physiological processes in mice, including: apoptosis, ion transport, inflammation, cell survival, and tumorigenesis. This study characterized the biological activity of Lcn-2 in human endometrial carcinoma cells (RL95-2). Exposure of RL95-2 cells to Lcn-2 for >24 h reduced Lcn-2-induced cell apoptosis, changed the cell proliferation and up-regulated cytokine secretions, including: interleukin-8 (IL-8), inteleukin-6 (IL-6), monocyte chemotatic protein-1 (MCP-1) and growth-related oncogene (GRO). However, IL-8 mRNA and protein levels were dramatically increased in Lcn-2-treated RL95-2 cells. To determine the IL-8 effect on Lcn-2-treated RL95-2 cells was our major focus. Adding recombinant IL-8 (rIL-8) resulted in decreased caspase-3 activity in Lcn-2-treated cells, whereas the addition of IL-8 antibodies resulted in significantly increased caspase-3 activity and decreased cell migration. Data indicate that IL-8 plays a crucial role in the induction of cell migration. Interestingly, Lcn-2-induced cytokines, secretion from RL95-2 cells, could not show the potent cell migration ability with the exception of IL-8. We conclude that Lcn -2 triggered cytokine secretions to prevent RL95-2 cells from undergoing apoptosis and subsequently increased cell migration. We hypothesize that Lcn-2 increased cytokine secretion by RL95-2 cells, which in turn activated a cellular defense system. This study suggests that Lcn-2 may play a role in the human female reproductive system or in endometrial cancer. ? Ivyspring International Publisher. | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.relation | INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 7(1), 74-86 | en |
dc.relation.ispartof | International Journal of Biological Sciences | - |
dc.subject | Apoptosis; Cellular defense; Cytokine secretion; Endometrial carcinoma cells | - |
dc.subject.other | Mus | - |
dc.subject.other | [SDGs]SDG3 | - |
dc.title | Lipocalin-2-induced cytokine production enhances endometrial carcinoma cell survival and migration | en |
dc.type | journal article | en |
dc.identifier.doi | 10.7150/ijbs.7.74 | - |
dc.relation.pages | 74-86 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/243416/-1/95.pdf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en_US | - |
item.fulltext | with fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
Appears in Collections: | 生化科學研究所 |
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