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  1. NTU Scholars
  2. 醫學院
  3. 臨床醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/144618
Title: Arsenic Cancer Risk Posed to Human Health from Tilapia Consumption in Taiwan
Authors: Liao C.-M.
Shen H.-H.
Lin T.-L.
Chen S.-C.
CHI-LING CHEN 
Hsu L.-I.
CHUNG-MIN LIAO 
LIAO, CHUNG- MIN
Keywords: arsenic;human health;epidemiology;bioaccumulation;tilapia;cancer;risk;blackfoot disease
Issue Date: 2008
Start page/Pages: 27-37
Source: Ecotoxicology and Environmental Safety 
Abstract: 
Ingested inorganic arsenic is strongly associated with a wide spectrum of adverse health outcomes. We propose a bioaccumulation and the Weibull model-based epidemiological framework to accurately estimate the reference arsenic intake guideline for tilapia consumption and tilapia- cultured water arsenic concentration based on bioaccumulations of tilapia and gender/age/cancer-specific epidemiological data from the arseniasis- endemic area in Taiwan. Our results show a positive relationship between arsenic exposure and age/gender- and cancer-specific cumulative incidence ratio using Weibull dose-response model . Based on male bladder cancer with an excess lifetime cancer risk of 10(-4), we estimate the reference tilapia inorganic arsenic guideline value to be 0.084 mu g g(-1) dry wt based on the suggested daily consumption rate of 120 g d (-1). Our findings show that consumption of tilapia in a blackfoot disease (BFD)- endemic area poses no significant cancer risk (excess cancer risks ranging from 3.4 x 10(-5) to 9.3 x 10(-5)), implying that people in BFD-endemic areas are not readily associated with higher fatalities for bladder cancer exposed from tilapia consumption. We are confident that our model can be easily adapted for other aquaculture species, and encourage risk managers to use the model to evaluate the potential population-level long-term low- dose cancer risks. We conclude that, by integrating the bioaccumulation concept and epidemiological investigation of humans exposed to arsenic, we can provide a scientific basis for risk analysis to enhance risk management strategies. (C) 2007 Elsevier Inc. All rights reserved.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/175420
DOI: 10.1016/j.ecoenv.2007.10.018
SDG/Keyword: [SDGs]SDG3
arsenic; aquaculture; arsenic; bioaccumulation; cancer; cichlid; dose-response relationship; estimation method; food consumption; health risk; modeling; pollution exposure; aquaculture; article; bioaccumulation; blackfoot disease; bladder cancer; cancer risk; endemic disease; health hazard; human; liver cancer; lung cancer; nonhuman; risk assessment; risk management; Taiwan; Tilapia; Animals; Arsenic; Carcinogens; Female; Food Contamination; Humans; Male; Models, Biological; Neoplasms; Risk Assessment; Taiwan; Tilapia; Water Pollutants, Chemical; Water Supply; Asia; Eurasia; Far East; Taiwan; Tilapia
Appears in Collections:臨床醫學研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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