|Title:||Ribavirin Enhances Interferon Signaling Via Stimulation of Mtor and P53 Activities||Authors:||SU, WEN-CHENG
|Keywords:||Ribavirin;mTOR;p53;IFN||Issue Date:||2009||Start page/Pages:||2793-2798||Source:||FEBS Letters||Abstract:||
Cellular mechanisms involving the enhancement of interferon( IFN) signaling by ribavirin remain poorly understood. Here, we identified a novel role of ribavirin in the communication between p53 and the mammalian target of rapamycin ( mTOR) signaling. Ribavirin activates p53 by stimulating mTOR and promoting the interaction between mTOR and p53. Activated p 53 stimulates the transcription of IFN regulatory factor 9 and subsequently enhances IFN signaling. Furthermore, ribavirin-induced activation of mTOR and p53 enhances IFN- dependent signaling for the IFN- alpha/ribavirin combined treatment. We conclude that ribavirin enhances activities of mTOR and p53, which may account for its antiviral and antitumor effects. Structured summary: MINT- 7222801: mTOR ( uniprotkb: P 42345) physically interacts (MI: 0914) with raptor ( uniprotkb: Q8N122) by anti bait coimmunoprecipitation ( MI: 0006) MINT-7222793: mTOR ( uniprotkb: P42345) physically interacts ( MI: 0914) with RICTOR (uniprotkb : Q8N6M7) by anti bait coimmunoprecipitation ( MI: 0006) MINT-7222784: mTOR ( uniprotkb: P42345) physically interacts ( MI: 0914) with P53 ( uniprotkb: P04637) by anti bait coimmunoprecipitation ( MI : 0006)
|Appears in Collections:||臨床醫學研究所|
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