Impact of Advanced GlycationEndproducts on Immune System and Its Signaling

Glycobiology, has been one of the most important advances in medical biology in recent decades. Advanced glycation endproducts(AGEs), as the most known stimulatory glycated protein and one of the markers of aging, have been investigated in many diseases, including Alzheimer''s disesase, atherosclerosis and diabetic mellitus. However, there is little literature discussing its roles in immunosenescence and immunosuppresion by AGEs. Herein, we designed this study, by transforming the extent of AGEs stimulation to the concentrations of AGEs, and observe the immunological effect on mononuclear cells. We find that biphasic change along with AGEs concentrations. This effect does not exist in different protein or glucose control. We also work on the mechanism and revealed that these responses are related to receptor of advanced glycation endproducts(RAGE) binding, Myd88, ERK and intranuclear NF-κB pathway. We expected such findings help us to further understand the influence of aging process and AGE production on immunity and pathogenesis of autoimmune diseases.