https://scholars.lib.ntu.edu.tw/handle/123456789/145395
標題: | A nationwide population-based study on bladder pain syndrome/interstitial cystitis and ED | 作者: | Chung, S-D Keller, J. Lin, H-C |
關鍵字: | BPS/IC;ED;epidemiology | 公開日期: | 2013 | 起(迄)頁: | 224-228 | 來源出版物: | International Journal of Impotence Research | 摘要: | As bladder pain syndrome/interstitial cystitis (BPS/IC) has been demonstrated to proceed through the inflammatory pathways to cause endothelial dysfunction, and endothelial dysfunction is a major factor in the development of ED, it is possible that BPS/IC may be associated with ED. This study set out to investigate the putative association between ED and BPS/IC by using a population-based data set and case-control design in Taiwan. We obtained the data from Taiwan's National Health Insurance Research Database. Cases included 32 856 ED patients >= 18-years old and 164 280 matched controls. Conditional logistic regression analyses were performed to compare the odds ratios (OR) and corresponding 95% confidence intervals (CIs) of having been previously diagnosed with BPS/IC in cases and controls. Among the total sample of 197 136 subjects, the prevalence of prior BPS/IC was 0.05%. The prevalence of prior BPS/IC was 0.10% and 0.04% for cases and controls, respectively (P<0.001). Conditional logistic regression analysis revealed that when compared with controls, the OR of prior BPS/IC for cases was 1.75 (95% CI=1.12-2.71) after adjusting for monthly income, geographic location, hypertension, diabetes, coronary heart disease, hyperlipidemia, renal disease, obesity, depressive disorder, alcohol abuse/alcohol-dependence syndromes and the number of outpatient visits within 1 year before index date. Subjects aged between 18 and 39 were additionally found to have the highest ORs for prior BPS/IC among cases when compared with controls (OR = 10.40; 95% CI = 2.93-36.94). There was an association between BPS/IC and ED. The youngest cases with ED were found to have the strongest magnitudes of association with BPS/IC. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/279615 | DOI: | 10.1038/ijir.2013.15 | SDG/關鍵字: | adult; aged; alcohol abuse; alcoholism; article; case control study; controlled study; cystalgia; depression; diabetes mellitus; disease association; endothelial dysfunction; female; geography; human; hyperlipidemia; hypertension; income; interstitial cystitis; ischemic heart disease; kidney disease; major clinical study; male; obesity; outpatient; population research; prevalence; priority journal; Taiwan; Adolescent; Adult; Aged; Case-Control Studies; Comorbidity; Cystitis, Interstitial; Endothelium; Erectile Dysfunction; Humans; Male; Middle Aged; Pain; Syndrome; Taiwan; Urinary Bladder |
顯示於: | 臨床醫學研究所 |
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