Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Clinical Medicine / 臨床醫學研究所
  4. Short-Term Effects of Kefir-Fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in a Randomized Clinical Trial of Osteoporotic Patients
 
  • Details

Short-Term Effects of Kefir-Fermented Milk Consumption on Bone Mineral Density and Bone Metabolism in a Randomized Clinical Trial of Osteoporotic Patients

Resource
PLoS One, 10(12),
Journal
PLoS ONE
Pages
e0144231
Date Issued
2015
Date
2015
Author(s)
Tu, Min-Yu
Chen, Hsiao-Ling
Tung, Yu-Tang
Kao, Chao-Chih
Hu, Fu-Chang
Chen, Chuan-Mu
Cameron, D William
DOI
10.1371/journal.pone.0144231
URI
http://ntur.lib.ntu.edu.tw//handle/246246/279742
Abstract
Milk products are good sources of calcium that may reduce bone resorption and help prevent bone loss as well as promote bone remodeling and increase bone formation. Kefir is a product made by kefir grains that degrade milk proteins into various peptides with health-promoting effects, including antithrombotic, antimicrobial and calcium-absorption enhancing bioactivities. In a controlled, parallel, double-blind intervention study over 6 months, we investigated the effects of kefir-fermented milk (1,600 mg) supplemented with calcium bicarbonate (CaCO3, 1,500 mg) and bone metabolism in 40 osteoporosis patients, and compared them with CaCO3 alone without kefir supplements. Bone turnover markers were measured in fasting blood samples collected before therapy and at 1, 3, and 6 months. Bone mineral density (BMD) values at the spine, total hip, and hip femoral neck were assessed by dual-energy x-ray absorptiometry (DXA) at baseline and at 6 months. Among patients treated with kefir-fermented milk, the relationships between baseline turnover and 6 months changes in DXA-determined BMD were significantly improved. The serum beta C-terminal telopeptide of type I collagen (beta-CTX) in those with T-scores > -1 patients significantly decreased after three months treatment. The formation marker serum osteocalcin (OC) turned from negative to positive after 6 months, representing the effect of kefir treatment. Serum parathyroid hormone (PTH) increased significantly after treatment with kefir, but decreased significantly in the control group. PTH may promote bone remodeling after treatment with kefir for 6 months. In this pilot study, we concluded that kefir-fermented milk therapy was associated with short-term changes in turnover and greater 6-month increases in hip BMD among osteoporotic patients.
SDGs

[SDGs]SDG3

Other Subjects
carboxy terminal telopeptide; osteocalcin; parathyroid hormone; calcium; calcium carbonate; collagen type 1; collagen type I trimeric cross-linked peptide; osteocalcin; parathyroid hormone; peptide; adult; aged; Article; blood sampling; bone density; bone metabolism; bone turnover; controlled study; diet supplementation; double blind procedure; dual energy X ray absorptiometry; female; fermented milk; food intake; human; major clinical study; male; milk; ossification; osteolysis; osteoporosis; parathyroid hormone blood level; pilot study; protein blood level; randomized controlled trial; therapy effect; treatment duration; blood; bone; clinical trial; diet therapy; dietary supplement; fermented milk product; metabolism; middle aged; osteoporosis; pathology; photon absorptiometry; placebo effect; treatment outcome; Absorptiometry, Photon; Aged; Bone and Bones; Bone Density; Calcium; Calcium Carbonate; Collagen Type I; Cultured Milk Products; Dietary Supplements; Double-Blind Method; Female; Humans; Male; Middle Aged; Osteocalcin; Osteoporosis; Parathyroid Hormone; Peptides; Placebo Effect; Treatment Outcome

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science