https://scholars.lib.ntu.edu.tw/handle/123456789/145543
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 臺大醫院-皮膚部;臺大醫院雲林分院;臺大醫學院-臨床醫學研究所; | - |
dc.contributor.author | Hsu, Tai-Yi | en_US |
dc.contributor.author | GUAN-YI HE | en_US |
dc.contributor.author | Wang, Yu-Chiao | en_US |
dc.contributor.author | Chen, Chih-Yu | en_US |
dc.contributor.author | Wang, Shih-Hao | en_US |
dc.contributor.author | Chen, Wei-Kung | en_US |
dc.contributor.author | Kao, Chia-Hung | en_US |
dc.creator | Hsu, Tai-Yi;He, Guan-Yi;Wang, Yu-Chiao;Chen, Chih-Yu;Wang, Shih-Hao;Chen, Wei-Kung;Kao, Chia-Hung | en |
dc.creator | 何冠頤 | zh-tw |
dc.date | 2015 | - |
dc.date.accessioned | 2017-06-22T07:44:22Z | - |
dc.date.accessioned | 2018-07-06T07:46:07Z | - |
dc.date.available | 2017-06-22T07:44:22Z | - |
dc.date.available | 2018-07-06T07:46:07Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/279763 | - |
dc.description.abstract | Alcohol use disorder (ADD) is considered a possible risk factor for irritable bowel syndrome (IBS); however, previous studies investigating the association between AUD and IBS have yielded inconsistent results. The study investigated whether ADD increases the risk of IBS by using a population-based database in Taiwan. This retrospective matched-cohort study included the health insurance claims data of 56,355 ADD inpatients and 225,420 randomly selected controls by frequency-matched for sex, age, and index year. Cox proportional hazards regression analysis was performed to measure the risk of IBS among AUD patients compared with non-AUD patients. During the follow-up period, the incidence rate ratio (IRR) of IBS had 12.3-fold (9552 CI: 11.9-12.7) in the AUD patients titan non-AUD patients and the adjusted hazard ratio (aHR) for IBS in the AUD patients was 5.51 (95% CI: 4.36-6.96). For several comorbidities, the risk of IBS was significantly higher in the ADD patients than in non-ADD patients, with aHRs of 2.14 (95% confidence interval [CI]: 1.19-3.84), 2.05 (95% CI: 1.06-3.96), and 2.91 (95% CI: 1.26-6.72) for sleep disorders, acute pancreatitis, and hepatitis B, respectively. When we stratified the severity of AUD according to the length of hospital stay, the aHRs exhibited a significant correlation (P < 0.001) with severity, yielding aHRs of 3.24 (95% CI: 2.49-4.22), 11.9 (95% CI: 8.96-15.9), and 26.1 (95% CI: 19.4-35.2) for mild, moderate, and severe AUD, respectively. ;The risk of IBS was higher among ADD patients, and increased with the length of hospital stay. | en_US |
dc.language | en-us | - |
dc.language.iso | en | en_US |
dc.relation | Medicine (Baltimore), 94(51), | en_US |
dc.relation.ispartof | Medicine | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | acute pancreatitis; adult; aged; alcohol use disorder; Article; cohort analysis; comorbidity; disease severity; female; follow up; health insurance; hepatitis B; hospital patient; hospitalization; human; investigative procedures; irritable colon; length of stay; major clinical study; male; priority journal; retrospective study; sleep disorder; Taiwan; task performance; age; Alcohol-Related Disorders; incidence; insurance; Irritable Bowel Syndrome; middle aged; proportional hazards model; risk factor; severity of illness index; sex difference; Adult; Age Factors; Aged; Alcohol-Related Disorders; Comorbidity; Female; Humans; Incidence; Insurance Claim Review; Irritable Bowel Syndrome; Male; Middle Aged; Proportional Hazards Models; Retrospective Studies; Risk Factors; Severity of Illness Index; Sex Factors; Taiwan | - |
dc.title | Alcohol Use Disorder Increases the Risk of Irritable Bowel Disease A Nationwide Retrospective Cohort Study | en_US |
dc.identifier.doi | 10.1097/MD.0000000000002334 | - |
dc.relation.pages | e2334 | en_US |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUHYL | - |
crisitem.author.orcid | 0000-0001-7096-8891 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital Yun-Lin Branch | - |
顯示於: | 臨床醫學研究所 |
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