https://scholars.lib.ntu.edu.tw/handle/123456789/146070
標題: | Molecular Epidemiology of Hiv-1 Subtypes in Taiwan: Outbreak of Hiv-1 Crf07_Bc Infection in Taiwan | 作者: | CHANG, SUI-YUAN SHENG, WANG-HUEI LEE, CHUN-NAN SUN, HSIN-YUN KAO, CHUAN-LIANG CHANG, SHU-FANG LIU, WEN-CHUN WONG, WING-WAI HUNG, CHIEN-CHING CHANG, SHAN-CHWEN |
公開日期: | 2006 | 卷: | v.22 | 期: | n.11 | 起(迄)頁: | 1055-1066 | 來源出版物: | AIDS RESEARCH AND HUMAN RETROVIROLOGY | 摘要: | In Taiwan, sexual transmission is responsible for most HIV- 1 infections with two dominant subtypes, subtype B and CRF01 _ AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of HIV-1 infection. To characterize the HIV isolates responsible for the outbreak among intravenous drug users (IDUs), phylogenetic analysis was performed to analyze the protease/RT sequences amplified from HIV-1- infected IDUs at National Taiwan University Hospital and Taipei City STD Control Center. CRF07_BC, which is circulating in northern China, was demonstrated to account for the majority of HIV-1 infection in IDUs in the past 2 years. Although these Taiwanese CRF07_BC sequences shared the same breakpoint positions as those described in the CRF 07_BC reference sequences, they formed a unique cluster in the phylogenetic tree, suggesting they originated from a founder virus. This finding was further supported by the relative low genetic diversity and unique sequence features. Our results demonstrated the emergence of CRF07_BC and its association with the HIV-1 outbreak among IDUs between 2004 and 2005 in Taiwan. This finding not only helps us to have a better understanding of the HIV evolution in Asia, but also has important implications for vaccine design in the future . |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/89816 |
顯示於: | 醫學檢驗暨生物技術學系 |
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