https://scholars.lib.ntu.edu.tw/handle/123456789/146070
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 醫學檢驗暨生物技術學系;內科部;內科 | en |
dc.contributor.author | CHANG, SUI-YUAN | en |
dc.contributor.author | SHENG, WANG-HUEI | en |
dc.contributor.author | LEE, CHUN-NAN | en |
dc.contributor.author | SUN, HSIN-YUN | en |
dc.contributor.author | KAO, CHUAN-LIANG | en |
dc.contributor.author | CHANG, SHU-FANG | en |
dc.contributor.author | LIU, WEN-CHUN | en |
dc.contributor.author | WONG, WING-WAI | en |
dc.contributor.author | HUNG, CHIEN-CHING | en |
dc.contributor.author | CHANG, SHAN-CHWEN | en |
dc.creator | 張淑媛;盛望徽;李君男;孫幸筠;高全良;張淑芳;劉玟君;王永衛;洪健清;張上淳 | zh-tw |
dc.creator | CHANG, SUI-YUAN;SHENG, WANG-HUEI;LEE, CHUN-NAN;SUN, HSIN-YUN;KAO, CHUAN-LIANG;CHANG, SHU-FANG;LIU, WEN-CHUN;WONG, WING-WAI;HUNG, CHIEN-CHING;CHANG, SHAN-CHWEN | en |
dc.date | 2006 | en |
dc.date.accessioned | 2008-12-08T03:15:15Z | - |
dc.date.accessioned | 2018-07-06T08:09:07Z | - |
dc.date.available | 2008-12-08T03:15:15Z | - |
dc.date.available | 2018-07-06T08:09:07Z | - |
dc.date.issued | 2006 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/89816 | - |
dc.description.abstract | In Taiwan, sexual transmission is responsible for most HIV- 1 infections with two dominant subtypes, subtype B and CRF01 _ AE, distributing among homosexual and heterosexual groups, respectively. Recently, intravenous drug use has become an emerging route of HIV-1 transmission and contributed to a significant increase of HIV-1 infection. To characterize the HIV isolates responsible for the outbreak among intravenous drug users (IDUs), phylogenetic analysis was performed to analyze the protease/RT sequences amplified from HIV-1- infected IDUs at National Taiwan University Hospital and Taipei City STD Control Center. CRF07_BC, which is circulating in northern China, was demonstrated to account for the majority of HIV-1 infection in IDUs in the past 2 years. Although these Taiwanese CRF07_BC sequences shared the same breakpoint positions as those described in the CRF 07_BC reference sequences, they formed a unique cluster in the phylogenetic tree, suggesting they originated from a founder virus. This finding was further supported by the relative low genetic diversity and unique sequence features. Our results demonstrated the emergence of CRF07_BC and its association with the HIV-1 outbreak among IDUs between 2004 and 2005 in Taiwan. This finding not only helps us to have a better understanding of the HIV evolution in Asia, but also has important implications for vaccine design in the future . | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | AIDS RESEARCH AND HUMAN RETROVIROLOGY v.22 n.11 pp.1055-1066 | en |
dc.relation.ispartof | AIDS RESEARCH AND HUMAN RETROVIROLOGY | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.title | Molecular Epidemiology of Hiv-1 Subtypes in Taiwan: Outbreak of Hiv-1 Crf07_Bc Infection in Taiwan | en |
dc.relation.pages | 1055-1066 | - |
dc.relation.journalvolume | v.22 | - |
dc.relation.journalissue | n.11 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。