|Title:||A Kinetic-Dynamic Model for Regulatory Rna Processing||Authors:||Singh, Sher
Yang, Hsiu-Yi Ou
|Keywords:||kinetic-dynamic model;pre-mRNA splicing;FCEA;FC adaptive||Issue Date:||2007||Source:||JOURNAL OF BIOTECHNOLOGY||Journal Volume:||v.127||Journal Issue:||n.3||Start page/Pages:||488-495||Abstract:||
A kinetic-dynamic model was proposed to simulate RNA processing by determining four essential reaction rates, including the rates of transcription, pre-mRNA turnover, pre -mRNA splicing, and mRNA decay. A family competition evolutionary algorithm (FCEA) was adapted herein to approximate these rates. Several artificial datasets were used to verify the correctness and robustness of the FCEA. The model was finally applied on time series data of yeast prp4-1 mutant cells for determination of rates of RNA processing. Based on the FCEA, the model indicated that the pre-mRNA splicing was decreased in the mutant cells as well as the possible effects on transcription, pre-mRNA turnover, and mRNA decay, which was consistent with surveyed literature. (c) 2006 Elsevier B.V. All rights reserved.
|Appears in Collections:||醫學檢驗暨生物技術學系|
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