|Title:||Familial Transmission of Human T-Lymphotropic Virus Type-I (Htlv-I) in Patients with Adult T-Cell Leukemia/Lymphoma or Htlv-I-Associated Myelopathy||Authors:||HU, CHUNG-YI
|Issue Date:||1998||Journal Volume:||v.97||Journal Issue:||n.2||Start page/Pages:||101-105||Source:||JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION||Abstract:||
The seroprevalence of human T-lymphotropic virus type 1 ( HTLV-1) in Taiwan is 0.48%. In this study, we investigated the patterns of intrafamilial transmission of HTLV-1 in Taiwanese patients with adult T- cell leukemia/lymphoma (ATL/ L) or tropical spastic paraparesis/HTLV-1- associated myelopathy (TSP/HAM). Fifteen index patients (9 men, 6 women , aged 31-71 yr), 13 with ATL/L, and two with TSP/HAM, and 98 relatives were included. Of the 98 relatives, 23 were seropositive for HTLV-1. Spouses of 11 patients were studied . Seven of eight wives of male patients but none of the three husbands of female patients were HTLV-1 carriers. Mother -to-child transmission was found in seven of 13 families and in 15 of 75 children tested. The correlation of breast-feeding with seropositivity in two families with seropositive mothers indicates its important role in vertical transmission of HTLV-1. Our findings suggest that husband-to-wife and mother-to-child transmission are the main forms of intrafamilial transmission of HTLV-1 in Taiwan , a nonendemic area. Screening for HTLV-1 in family members of patients with ATL/L or TSP/HAM, and seropositive blood donors, may be warranted. Seropositive individuals should be educated to prevent the spread of the virus through sexual contact and breast feeding.
|Appears in Collections:||醫學檢驗暨生物技術學系|
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