https://scholars.lib.ntu.edu.tw/handle/123456789/146095
標題: | Familial Transmission of Human T-Lymphotropic Virus Type-I (Htlv-I) in Patients with Adult T-Cell Leukemia/Lymphoma or Htlv-I-Associated Myelopathy | 作者: | HU, CHUNG-YI LIN, MING-TSEH YANG, YA-CHIEN TANG, JIH-LUH TSENG, LI-HUI CHEN, YAO-CHANG YANG, CZAU-SIUNG WANG, CHIU-HWA |
公開日期: | 1998 | 卷: | v.97 | 期: | n.2 | 起(迄)頁: | 101-105 | 來源出版物: | JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION | 摘要: | The seroprevalence of human T-lymphotropic virus type 1 ( HTLV-1) in Taiwan is 0.48%. In this study, we investigated the patterns of intrafamilial transmission of HTLV-1 in Taiwanese patients with adult T- cell leukemia/lymphoma (ATL/ L) or tropical spastic paraparesis/HTLV-1- associated myelopathy (TSP/HAM). Fifteen index patients (9 men, 6 women , aged 31-71 yr), 13 with ATL/L, and two with TSP/HAM, and 98 relatives were included. Of the 98 relatives, 23 were seropositive for HTLV-1. Spouses of 11 patients were studied . Seven of eight wives of male patients but none of the three husbands of female patients were HTLV-1 carriers. Mother -to-child transmission was found in seven of 13 families and in 15 of 75 children tested. The correlation of breast-feeding with seropositivity in two families with seropositive mothers indicates its important role in vertical transmission of HTLV-1. Our findings suggest that husband-to-wife and mother-to-child transmission are the main forms of intrafamilial transmission of HTLV-1 in Taiwan , a nonendemic area. Screening for HTLV-1 in family members of patients with ATL/L or TSP/HAM, and seropositive blood donors, may be warranted. Seropositive individuals should be educated to prevent the spread of the virus through sexual contact and breast feeding. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/105249 |
顯示於: | 醫學檢驗暨生物技術學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。