https://scholars.lib.ntu.edu.tw/handle/123456789/146164
標題: | Pan-Drug-Resistant Pseudomonas Aeruginosa Causing Nosocomial Infection at a University Hospital in Taiwan | 作者: | HO, SHEN-WU TENG, LEE-JENE HSUEH, PO-REN |
關鍵字: | Colistin;pan-drug resistance;Pseudomonas aeruginosa;synergism;time-kill studies | 公開日期: | 2005 | 卷: | v.11 | 期: | n.8 | 起(迄)頁: | 670-673 | 來源出版物: | CLINICAL MICROBIOLOGY & INFECTION | 摘要: | This study evaluated the clinical and microbiological characteristics of 16 patients who were colonised or infected with 26 isolates of pan-drug- resistant Pseudomonas aeruginosa (PDRPA; intermediately-resistant or resistant to all cephalosporins, piperacillin–tazobactam, aztreonam, carbapenems, ciprofloxacin and aminoglycosides) in a university hospital during 1999–2002. All the isolates had colistin MICs ≤ 4 mg/L, 19 ( 73%) isolates had blaVIM-3 , and 25 (96%) isolates had class I integrons ( intI). Time- kill studies for two PDRPA blood isolates demonstrated synergism for cefepime–amikacin after 24 h. Pulsed-field gel electrophoresis analysis of the isolates revealed a polyclonal nature (12 pulsotypes), although clonal dissemination of PDRPA isolates among these patients was also present. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/105301 |
顯示於: | 醫學檢驗暨生物技術學系 |
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