Dynamic analysis of insulin and glucagon secretions
Resource
Engineering in Medicine and Biology Society, 1995. IEEE 17th Annual Conference
Journal
Engineering in Medicine and Biology Society, 1995. IEEE 17th Annual Conference
Pages
-
Date Issued
1995-09
Date
1995-09
Author(s)
Yao, Nan-Kang
DOI
N/A
Abstract
The interaction between insulin and glucagon secretions in an negative-positive relationship bolstered the concept that the net secretion of pancreatic hormones might be the product of specific interaction within the islet. However, how the interaction between A and B cells influences the secretion cycles is unclear. The authors developed a cell culture-microperifusion system that allowed them to study the detailed dynamics of pulsatile secretions for both hormones. The power spectrum and cross-correlation analysis were used to investigate their oscillation features and phase relationship. The result showed that both insulin and glucagon secretions behaved in a spontaneous, persistent, regular, pulsatile and out-of-phase fashion. The authors suggest that insulin is dominant in the interactive process, i.e., insulin is a master and glucagon is a slave.
Type
journal article
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