|Title:||Effects of Penicillin on Procaine-Elicited Bursts of Potential in Central Neuron of Snail, Achatina Fulica||Authors:||CHEN, YI-HUNG
HSIAO, RU- WAN
TSAI, MING- CHENG
|Keywords:||ascorbate;bursts of potential;L-NAME;neuron;procaine;penicillin;snail;sodium current||Issue Date:||2008||Start page/Pages:||128-135||Source:||Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology||Abstract:||
Effects of penicillin on changes in procaine-elicited bursts of potential (BoP) were studied in a central neuron (RP4) of snail, Achatina fulica Ferussac. Procaine elicited BoP in the RP4 neuron while penicillin elicited depolarization of the neuron. Penicillin decreased the BoP elicited by procaine in a concentration-dependent manner. The effect of penicillin on the procaine-elicited BoP was not altered in the preparations treated with ascorbate or L-NAME (N-nitro-L -arginine methyl ester). However, the inhibitory effect of penicillin on the procaine- elicited BoP was enhanced with a decrease in extracellular sodium ion. Sodium ion was one of the important ions contributing to the action potential of the neuron. Two-electrode voltage-clamp studies revealed that penicillin decreased the fast sodium inward current of the neuron. It is concluded that penicillin inhibited the BoP elicited by procaine and sodium ion altered the effect of penicillin on procaine-elicited BoP.
|Appears in Collections:||護理學系所|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.