DC 欄位 | 值 | 語言 |
dc.contributor | 臺大醫院-小兒部;臺大醫院-外科部;臺大醫院-核子醫學部;臺大醫學院-護理學系暨研究所; | en |
dc.contributor.author | Lu, Meng-Yao | en |
dc.creator | Lu, Meng-Yao;Liu, Yen-Lin;Chang, Hsiu-Hao;Jou, Shiann-Tarng;Yang, Yung-Li;Lin, Kai-Hsin;Lin, Dong-Tsamn;Lee, Ya-Ling;Lee, Hsinyu;Wu, Pei-Yi;Luo, Tsai-Yueh;Shen, Lie-Hang;Huang, Shiu-Feng;Liao, Yung-Feng;Hsu, Wen-Ming;Tzen, Kai-Yuan | en |
dc.creator | 林東燦 ;許文明 ;曾凱元 ;周獻堂 ;盧孟佑 ;張修豪 ;林凱信 ;楊永立 ;李雅玲 | zh-tw |
dc.date | 2013 | en |
dc.date.accessioned | 2014-02-14T08:56:44Z | - |
dc.date.accessioned | 2018-07-07T02:00:26Z | - |
dc.date.available | 2014-02-14T08:56:44Z | - |
dc.date.available | 2018-07-07T02:00:26Z | - |
dc.date.issued | 2013 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/259661 | - |
dc.description.abstract | Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and can theoretically be imaged by F-18-fluorodihydroxyphenylalanine (F-18-FDOPA) PET, a new diagnostic tool for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of F-18-FDOPA PET in neuroblastic tumors. Methods: From 2008 to 2011, patients with tissue-proven neuroblastic tumors receiving F-18-FDOPA PET at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of F-18-FDOPA PET were compared with those of I-123-metaiodobenzylguanidine (I-123-MIBG) scintigraphy and F-18-FDG PET, using tumor histology as the standard. The maximum standardized uptake value and tumor-to-liver uptake ratio on F-18-FDOPA PET were measured and correlated with AADC messenger RNA level in tumor tissue. Results: Fifty tumors from 34 patients, including 42 neuroblastic tumors and 8 lesions without viable tumor cells, were eligible for analysis. F-18-FDOPA PET successfully detected neuroblastic tumors of different histologic types in various anatomic sites, at a sensitivity of 97.6% (87.4%-99.9%) and a specificity of 87.5% (47.3%-99.7%). In tumors with concomitant studies, F-18-FDOPA PET demonstrated a higher sensitivity than I-123-MIBG scintigraphy (n = 18; P = 0.0455) or F-18-FDG PET (n = 46; P = 0.0455). Among the 18 tumors with concomitant I-123-MIBG scans, 4 tumors with viable cells were I-123-MIBG negative but were successfully detected by F-18-FDOPA PET. The tumor uptake of F-18-FDOPA significantly correlated with AADC expression (17 = 15 nonhepatic tumors; maximum standardized uptake value, P = 0.0002; tumor-to-liver uptake ratio, P < 0.0001). Conclusion: F-18-FDOPA PET showed high sensitivity and specificity in detecting and tracking neuroblastic tumors in this preliminary study with a small cohort of patients and might be complementary to I-123-MIBG scintigraphy and F-18-FDG PET. By correlating with AADC expression, F-18-FDOPA PET might serve as a useful imaging tool for the functional assessment of neuroblastic tumors. | en |
dc.format.extent | 107 bytes | - |
dc.format.mimetype | text/html | - |
dc.language | en-us | en |
dc.relation | J. Nucl. Med., 54(1), 42-49 | en |
dc.relation.ispartof | J. Nucl. Med. | - |
dc.subject | neuroblastoma | en |
dc.subject | ganglioneuroma | en |
dc.subject | F-18-FDOPA | en |
dc.subject | positron emission tomography | en |
dc.subject | sensitivity and specificity | en |
dc.title | Characterization of Neuroblastic Tumors Using F-18-FDOPA PET | en |
dc.relation.pages | 42-49 | - |
dc.relation.journalvolume | 54 | - |
dc.relation.journalissue | 1 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/259661/1/index.html | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 護理學系所
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