Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Physical Therapy / 物理治療學系所
  4. Investigation of Potential Biomarkers for the Susceptibility of Bronchopulmonary Dysplasia and Normative Data for a Preschool Behavioral and Emotional Assessment in Taiwanese Preterm Children
 
  • Details

Investigation of Potential Biomarkers for the Susceptibility of Bronchopulmonary Dysplasia and Normative Data for a Preschool Behavioral and Emotional Assessment in Taiwanese Preterm Children

Date Issued
2011
Date
2011
Author(s)
Wu, Yen-Tzu
URI
http://ntur.lib.ntu.edu.tw//handle/246246/250537
Abstract
Chapter 1 Background: Genetic factors have been shown to account for more than 50% of the variation in bronchopulmonary dysplasia (BPD) in preterm infants. However, human genetic association studies have failed to show consistent associations, and altered expression of transcription factors has only been observed in animal studies. An emerging focus in the search for biomarkers of BPD has been on post-transcriptional regulator of messenger RNA translation such as microRNAs (miRNAs). Objective: This study aimed to identify differentially expressed miRNAs in the peripheral blood of very low birth weight (VLBW, birth weight < 1,500 g) preterm infants with and without BPD. Methods: Blood samples from 15 VLBW preterm infants with BPD and from 15 sex-matched controls were collected in early postnatal life, and 365 miRNA expression profiles were assessed using a quantitative real-time polymerase chain reaction system. Results: The BPD group was more likely than the non-BPD group to show increased expression of miR-133b and miR-7 and decreased expression of miR-152, miR-30a-3p, miR-650 and miR-624 (all p < 0.2). This 6-miRNA signature was highly predictive of the occurrence of BPD after controlling for the effects of confounders (accuracy = 0.995). Forty-one shared target genes were associated with the 6-miRNA signature, and seventeen of them were relevant to development-related functions and diseases. The Wnt/β-catenin and axon guidance signaling pathways were associated with the target genes (p < 0.05 for both). Conclusions: This 6-miRNA signature of peripheral blood might serve as a biomarker predictive of the occurrence of BPD in VLBW preterm infants. Chapter 2 Background: There has been limited epidemiologic information concerning non-Western preschoolers’ behavioral and emotional problems, and the data in Taiwanese preschoolers is lacking. Objective: This study aimed to investigate behavioral and emotional problems in a full-term population of Taiwanese preschoolers using the Child Behavior Checklist for Ages 1½-5 (CBCL/1½-5). The behavioral problems scores and prevalence of Taiwanese preschoolers were compared with those of American and Dutch preschoolers. The correlates of behavioral problems were also examined. Methods: Mothers of 306 Taiwanese preschoolers aged 20-60 months completed the CBCL/1½-5. The data of American and Dutch preschoolers were extracted from the previous studies and to compare with Taiwanese data. Results: The CBCL/1½-5 had satisfactory reliability and factorial validity for assessing Taiwanese preschoolers. Results of cross-cultural comparisons revealed that Taiwanese preschoolers exhibited higher behavioral problem scores on most of the behavioral syndromes and increased prevalence rates of internalizing-related syndromes and Sleep Problems. Younger age, male gender, and first birth order were unfavorable for behavioral performance. Girls’ behavioral problems decreased with age, whereas boys’ behavioral problems persistently high across ages. Conclusions: Results of cross-cultural comparisons and behavioral correlates are important to assist in clinical assessment and management of preschoolers’ behavioral and emotional problems.
Subjects
Preterm
bronchopulmonary dysplasia
biomarker
preschool
behavioral/emotional problem
microRNA
Very low birth weight
CBCL/11/2-5
pervalence rate
behavioral correlates
SDGs

[SDGs]SDG3

File(s)
Loading...
Thumbnail Image
Name

ntu-100-D94428002-1.pdf

Size

23.32 KB

Format

Adobe PDF

Checksum

(MD5):f2eae42cdb434c22aac5022b0e1414f7

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science