Frequency-Dependent Cortical Excitability in Rhythmic Movement with Auditory Cues in Parkinson’s Disease
Date Issued
2015
Date
2015
Author(s)
Hung, Yu-Ting
Abstract
Background: External cues are widely applied on training motor functions in movement disorder such as Parkinson’s disease (PD). In our previous study, changes in the motor cortex excitability were shown the 2 Hz finger tapping with auditory cue might modulate the cortical activity in PD patients. However, movements of human subjects are not restricted to a specific rhythm, and physical therapists use external cues across different frequencies depending on patients’ status in rehabilitation. Frequency-dependent movement activities were reported in present studies. It is still unclear whether motor cortex activity reveals a frequency-dependent pattern at different rates in PD. Objective：The performance and motor cortex excitability of frequency-dependent finger movements with auditory cue in patients with PD were investigated in this study. To explore the mechanism underlying the auditory cued training across different frequencies, changes of motor cortex excitability were obtained by using transcranial magnetic stimulation (TMS). Methods: This study was a cross-over study. A total of twenty-five patients (H & Y stage I-III) were randomly assigned to 1 Hz (12 patients, 64.2 ± 8.0 years) or 3 Hz (13 patients, 61.4 ± 9.4 years) group. All participants received two sessions of experiment in random order, one was external-triggered condition which received auditory cue while performed movements, and self-initiated condition which performed movement after listened to required rhythm. Results: After training with auditory cues, CV of fast tapping only significantly decreased in 2 Hz condition (p= .032). There were significant increase of short intracortical inhibition (SICI) (1 Hz: p= .002; 2 Hz: p< .001; 3Hz: p< .001) and significant difference between ET and SI conditions (1 Hz: p< .001; 2 Hz: p= .005; 3Hz: p= .011). Significant post-training decrease of intracortical facilitation (ICF) in 1 Hz and 3 Hz groups (1 Hz: p= .006; 3Hz: p= .002). Additionally, ICF was significantly different between 1 Hz and 2 Hz conditions (p= .001), 2 Hz and 3 Hz conditions (p= .008). Conclusions: Only 2 Hz auditory cues had significant benefit in rhythmic movements. Though 1 Hz, 2 Hz and 3 Hz cues were able to modulate the cortical excitability in the motor cortex, the mechanisms involved in the application of auditory cues still needed more studies.
Subjects
Auditory cue
Parkinson’s disease
frequency
motor performance
motor cortex excitability
SDGs
Type
thesis
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