Intensity modulated radiotherapy for elderly bladder cancer patients
Resource
Radiation Oncology, 6, 75
Journal
Radiation Oncology
Pages
75
Date Issued
2011
Date
2011
Author(s)
Hsieh C.-H.
Chung S.-D.
Chan P.-H.
Lai S.-K.
Chang H.-C.
Hsiao C.-H.
Wu L.-J.
Chong N.-S.
Chen Y.-J.
Hsieh Y.-P.
Shueng P.-W.
Abstract
Background: To review our experience and evaluate treatment planning using intensity-modulated radiotherapy (IMRT) and helical tomotherapy (HT) for the treatment of elderly patients with bladder cancer.Methods: From November 2006 through November 2009, we enrolled 19 elderly patients with histologically confirmed bladder cancer, 9 in the IMRT and 10 in the HT group. The patients received 64.8 Gy to the bladder with or without concurrent chemotherapy. Conventional 4-field "box" pelvic radiation therapy (2DRT) plans were generated for comparison.Results: The median patient age was 80 years old (range, 65-90 years old). The median survival was 21 months (5 to 26 months). The actuarial 2-year overall survival (OS) for the IMRT vs. the HT group was 26.3% vs .37.5%, respectively; the corresponding values for disease-free survival were 58.3% vs. 83.3%, respectively; for locoregional progression-free survival (LRPFS), the values were 87.5% vs. 83.3%, respectively; and for metastases-free survival, the values were 66.7% vs. 60.0%, respectively. The 2-year OS rates for T1, 2 vs. T3, 4 were 66.7% vs. 35.4%, respectively (p = 0.046). The 2-year OS rate was poor for those whose RT completion time greater than 8 weeks when compared with the RT completed within 8 wks (37.9% vs. 0%, p = 0.004).Conclusion: IMRT and HT provide good LRPFS with tolerable toxicity for elderly patients with invasive bladder cancer. IMRT and HT dosimetry and organ sparing capability were superior to that of 2DRT, and HT provides better sparing ability than IMRT. The T category and the RT completion time influence OS rate. ? 2011 Hsieh et al; licensee BioMed Central Ltd.
SDGs
Other Subjects
adult; aged; article; bladder cancer; cancer patient; controlled study; disease free survival; female; human; intensity modulated radiation therapy; major clinical study; male; overall survival; progression free survival; tomotherapy; bladder tumor; computer assisted radiotherapy; computer assisted tomography; intensity modulated radiation therapy; metastasis; methodology; radiation response; radiometry; retrospective study; treatment outcome; Aged; Aged, 80 and over; Disease-Free Survival; Dose-Response Relationship, Radiation; Female; Humans; Male; Neoplasm Metastasis; Radiometry; Radiotherapy Planning, Computer-Assisted; Radiotherapy, Intensity-Modulated; Retrospective Studies; Tomography, X-Ray Computed; Treatment Outcome; Urinary Bladder Neoplasms
Type
journal article
File(s)![Thumbnail Image]()
Loading...
Name
43.pdf
Size
23.15 KB
Format
Adobe PDF
Checksum
(MD5):8606b5c0c6dbfb5df0cf5b925cb5b81c