https://scholars.lib.ntu.edu.tw/handle/123456789/160015
標題: | DNA methyltransferase gene dDnmt2 and longevity of Drosophila | 作者: | Lin, M.J. Tang, L.Y. Reddy, M.N. Shen, James C.K. |
公開日期: | 14-一月-2005 | 出版社: | Taipei:National Taiwan University Dept Chem Engn | 期: | No. 2 | 起(迄)頁: | - | 來源出版物: | THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 280 | 摘要: | The DNA methylation program of the fruit fly Drosophila melanogaster is carried out by the single DNA methyltransferase gene dDnmt2, the function of which is unknown before. We present evidence that intactness of the gene is required for maintenance of the normal life span of the fruit flies. In contrast, overexpression of dDnmt2 could extend Drosophila life span. The study links the Drosophila DNA methylation program with the small heatshock proteins and longevity/aging and has interesting implication on the eukaryotic DNA methylation programs in general. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/2006111501221930 | 其他識別: | 246246/2006111501221930 |
顯示於: | 分子醫學研究所 |
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