https://scholars.lib.ntu.edu.tw/handle/123456789/160061
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 分子醫學研究所 | en |
dc.contributor.author | CHEN, RUEY-HWA | en |
dc.creator | 陳瑞華 | zh-tw |
dc.creator | CHEN, RUEY-HWA | en |
dc.date | 2002 | en |
dc.date.accessioned | 2008-12-29T06:53:13Z | - |
dc.date.accessioned | 2018-07-09T01:15:47Z | - |
dc.date.available | 2008-12-29T06:53:13Z | - |
dc.date.available | 2018-07-09T01:15:47Z | - |
dc.date.issued | 2002 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/95069 | - |
dc.description.abstract | Transforming growth factor-beta (TGF-beta) and TGF-beta- related factors induce apoptosis in a variety of tissues; however, the mechanism underlying this induction is largely unknown. Here, we demonstrate that TGF-beta induces the expression of the death-associated protein kinase ( DAP- kinase) as an immediate early response in cells that undergo apoptosis in response to TGF-beta. DAP-kinase is a positive mediator of apoptosis induced by certain cytokines and oncogenes. We show that the DAP -kinase promoter is activated by TGF-beta through the action of Smad2, Smad3 and Smad4. Overexpression of DAP-kinase triggers apoptosis in the absence of TGF-beta, whereas inhibition of DAP-kinase activity protects cells from TGF-beta-induced apoptosis, blocks TGF-beta-induced release of cytochrome c from mitochondria and prevents TGF-beta-induced dissipation of the mitochondrial membrane potential. Our findings indicate that DAP- kinase mediates TGF-beta-dependent apoptosis by linking Smads to mitochondrial-based pro-apoptotic events. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | NATURE CELL BIOLOGY v.4 n.1 pp.51-58 | en |
dc.relation.ispartof | NATURE CELL BIOLOGY | - |
dc.subject | GROWTH-FACTOR-BETA | en |
dc.subject | PROGRAMMED CELL-DEATH | en |
dc.subject | TRANSFORMING GROWTH -FACTOR-BETA-1 | en |
dc.subject | FUNCTIONAL COOPERATION | en |
dc.subject | SIGNALING PATHWAYS | en |
dc.subject | DOWN-REGULATION | en |
dc.title | Tgf-Beta Induces Apoptosis through Smad-Mediated Expression of Dap-Kinase | en |
dc.relation.pages | 51-58 | - |
dc.relation.journalvolume | v.4 | - |
dc.relation.journalissue | n.1 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
顯示於: | 分子醫學研究所 |
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