Comparison with the serum levels of soluble co-stimulatory factors and adhesion molecules in patients with active rheumatoid arthritis and systemic lupus erythematosus
Date Issued
2009
Date
2009
Author(s)
Chen, Chao-Yi
Abstract
Co-stimulatory molecules connecting with leukocyte adhesion molecules play an important role in responses to T lymphocyte and leukocyte-mediated inflammatory. The aim of the study was to analyze serum concentrations of soluble co-stimulatory molecules (sCTLA-4, sCD28, sCD80, sCD86) and soluble cell adhesion molecules (sE-selectin, sICAM-1, sVCAM-1) among 16 active rheumatoid arthritis (RA) patients, 20 Systemic Lupus Erythematosus (SLE) patients and 8 healthy controls. The analysis method was based on a quantitative sandwich enzyme-linked immunosorbent assay (ELISA).ompared with healthy control subjects (all p<0.05), serum levels of sCTLA-4 was significantly lower in active RA patients, whereas sCD80, sE-selectin, sICAM-1 and sVCAM-1 were significantly higher. In SLE patients, serum levels of sCTLA-4 and sE-selectin were significantly lower whereas sCD86 was significantly higher when comparing with healthy control subjects (all p<0.05).n addition, the comparison of the serum levels of soluble co-stimulatory and cell adhesion molecules between active RA and SLE patients indicates the characteristics of active RA patients, that is the decreasing levels of sCTLA-4 and elevated levels of sCD80, sE-selectin, sICAM-1 and sVCAM-1. The comparison also indicates the characteristics of active SLE patients , that are the decreasing levels of sCTLA-4 and sE-selectin and elevated levels of sCD86.herefore, the study indicates that the aberrant expression of soluble co-stimulatory and cell adhesion molecules activates T cells and leukocytes. And this may be the cause for the inflammation and has the distinctness in active RA and SLE patients.
Subjects
soluble co-stimulatory factors
adhesion molecules
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