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  4. The Role of SIK2 in Aggresome Processing
 
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The Role of SIK2 in Aggresome Processing

Date Issued
2009
Date
2009
Author(s)
Lin, Ya-Huei
URI
http://ntur.lib.ntu.edu.tw//handle/246246/178736
Abstract
SIK2 (salt-inducible kinase 2) belongs to members of AMPK family. The functions of SIK2 other than the regulation of insulin signal transduction and adipocyte differentiation are poorly understood. Recently, we showed that SIK2 interacts with p97 to regulate ER-associated protein degradation (ERAD). In this study, we further demonstrated that SIK2 plays important function in aggresome processing. Using proteasome inhibitor (e.g., MG132)- and C-terminal truncated TDP-43-induced inclusion bodies/aggresomes as models, we found that SIK2 and p97 co-localize toggresomes. Overexpression of SIK2 caused decrease while knockdown of SIK2 resulted in increase of inclusion bodies/aggresomes. It may facilitate aggresome processing through interacting with p97. Further experiments suggest that SIK2 may influence the turnover of autophagosomes. Our study demonstrated that SIK2 coulderve as a positive regulator in autophagic-mediated protein degradation.
Subjects
aggresomes
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