https://scholars.lib.ntu.edu.tw/handle/123456789/160202
標題: | Wnt對線蟲Q細胞極性和移動的調控 Wnt Signaling regulates Q Neuroblast Cell Polarization and Migration in Caenorhabditis elegans |
作者: | 陳忠寬 Chen, Chung-Kuan |
關鍵字: | 秀麗線蟲;Q細胞;細胞遷移;Wnt信號傳遞;Hox基因 | 公開日期: | 2014 | 摘要: | Neuronal migration is an essential process that establishes the intricate and precise connectivity of the nervous system. Here, we study the molecular mechanisms of neuronal migration, using Q neuroblast lineages in C.elegans as a model. The left and right Q neuroblasts are equivalent lineages that show distinct migratory patterns along the antero-posterior axis. The Q descendants on the left (QL) migrate posteriorly, whereas those on the right (QR) migrate anteriorly. The posterior QL descendant migration requires the EGL-20/Wnt-dependent Hox gene mab-5. mab-5 repressed another Hox gene, lin-39, whose expression would otherwise promote anterior migration. In addition to this transcriptional regulation, another Wnt CWN-1 and Frizzled receptor MOM-5 promote QR anterior migration. We found that CWN-1/MOM-5 and LIN-39 act in parallel to promote Q cell anterior migration. CWN-1 instructed QR.pa anterior polarization and also influences the polarization of QL.pa that lacked EGL-20/MAB-5 signaling. We show that the Frizzleds MIG-1 and MOM-5 were expressed and functioned autonomously in the QL and QR descendants. Furthermore, we found that the planar cell polarity gene vang-1, which is the C. elegans homolog of the mammalian Vangl2 and Drosophila van Gogh/Strabismus, strongly suppressed QL anterior migration in the mig-1 mutant, and improved QR undermigration in the cwn-1 or egl-20 mutants. These data suggest that PCP genes regulate the Q cell migration. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/261127 | Rights: | 論文使用權限:同意有償授權(權利金給回饋學校) |
顯示於: | 分子醫學研究所 |
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ntu-103-R01448011-1.pdf | 23.32 kB | Adobe PDF | 檢視/開啟 |
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