https://scholars.lib.ntu.edu.tw/handle/123456789/160261
DC Field | Value | Language |
---|---|---|
dc.contributor | 分子醫學研究所 | en |
dc.contributor.author | LIN, YU-MIN | en |
dc.contributor.author | KAO, TE-CHAN | en |
dc.contributor.author | CHEN, RUEY-HWA | en |
dc.creator | 林裕敏;高德展;陳瑞華 | zh-tw |
dc.creator | LIN, YU-MIN;KAO, TE-CHAN;CHEN, RUEY-HWA | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-07-05T09:40:49Z | - |
dc.date.accessioned | 2018-07-09T01:21:59Z | - |
dc.date.available | 2012-07-05T09:40:49Z | - |
dc.date.available | 2018-07-09T01:21:59Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/240679 | - |
dc.description.abstract | The induction of neurite outgrowth and arborization is critical for developmental and regenerative processes. In this paper, we report that the BTB-kelch protein KLHL20 promoted neurite outgrowth and arborization in hippocampal and cortical neurons through its interaction with Cullin3 to form a ubiquitin ligase complex. This complex targeted PDZ- Rho guanine nucleotide exchange factor RhoGEF, a protein abundantly expressed in the brain, for ubiquitin-dependent proteolysis, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth. Importantly, targeting PDZ-RhoGEF to KLHL20 required PDZ- RhoGEF phosphorylation by p38 mitogen-activated protein kinase. In response to p 38-activating neurotrophins, such as brain-derived neurotrophic factor and neurotrophin-3, KLHL 20-mediated PDZ-RhoGEF destruction was potentiated, leading to neurotrophin-induced neurite outgrowth. Our study identified a ubiquitin-dependent pathway that targets PDZ- RhoGEF destruction to facilitate neurite outgrowth and indicates a key role of this pathway in neurotrophin-induced neuronal morphogenesis. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | JOURNAL OF CELL BIOLOGY v.193 n.6 pp.985-994 | en |
dc.relation.ispartof | JOURNAL OF CELL BIOLOGY | - |
dc.title | Pdz-Rhogef Ubiquitination by Cullin3-Klhl20 Controls Neurotrophin-Induced Neurite Outgrowth | en |
dc.relation.pages | 985-994 | - |
dc.relation.journalvolume | v.193 | - |
dc.relation.journalissue | n.6 | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
Appears in Collections: | 分子醫學研究所 |
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