https://scholars.lib.ntu.edu.tw/handle/123456789/160265
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 分子醫學研究所 | en |
dc.contributor.author | PAN, CHUN-LIANG | en |
dc.creator | 潘俊良;彭秋瑩;陳俊豪 | zh-tw |
dc.creator | PAN, CHUN-LIANG;PENG, CHIU-YING;CHEN, CHUN-HAO | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-07-05T09:51:58Z | - |
dc.date.accessioned | 2018-07-09T01:22:01Z | - |
dc.date.available | 2012-07-05T09:51:58Z | - |
dc.date.available | 2018-07-09T01:22:01Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/240690 | - |
dc.description.abstract | Although many genes have been implicated in the pathogenesis of common neurodegenerative diseases, the genetic and cellular mechanisms that maintain neuronal integrity during normal aging remain elusive. Here we show that Caenorhabditis elegans touch receptor and cholinergic neurons display age-dependent morphological defects, including cytoskeletal disorganization, axon beading, and defasciculation. Progression of neuronal aging is regulated by DAF-2 and DAF-16 signaling, which also modulate adult life span. Mutations that disrupt touch-evoked sensory activity or reduce membrane excitability trigger accelerated neuronal aging, indicating that electrical activity is critical for adult neuronal integrity. Disrupting touch neuron attachment to the epithelial cells induces distinct neurodegenerative phenotypes. These results provide a detailed description of the age-dependent morphological defects that occur in identified neurons of C. elegans, demonstrate that the age of onset of these defects is regulated by specific genes, and offer experimental evidence for the importance of normal levels of neural activity in delaying neuronal aging. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA v.108 n.22 pp.9274-9279 | en |
dc.relation.ispartof | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.subject | extracellular matrix | en |
dc.subject | insulin signaling | en |
dc.subject | ion channels | en |
dc.subject | mechanosensory neurons | en |
dc.subject | neurodegeneration | en |
dc.title | Genetic Analysis of Age-Dependent Defects of the Caenorhabditis Elegans Touch Receptor Neurons | en |
dc.relation.pages | 9274-9279 | - |
dc.relation.journalvolume | v.108 | - |
dc.relation.journalissue | n.22 | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
顯示於: | 分子醫學研究所 |
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