Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Immunology / 免疫學研究所
  4. The role of NF-κB signaling pathway in TRAIL-induced costimulation of T cells
 
  • Details

The role of NF-κB signaling pathway in TRAIL-induced costimulation of T cells

Date Issued
2007
Date
2007
Author(s)
Yang, Cheng-Yuan
DOI
en-US
URI
http://ntur.lib.ntu.edu.tw//handle/246246/63338
Abstract
Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) is a member of the TNF superfamily which is capable of inducing apoptosis in transformed cells but not in most of the primary cells. In our previous study, we demonstrated that TRAIL stimulated with immobilized DR4, in conjunction with suboptimal anti-CD3, induced T cell proliferation and enhanced IFN-gamma production. This indicates that TRAIL can transduce reverse signal to induce T cell activation. Furthermore, we found that PI3K/Akt activity was enhanced after TRAIL-mediated T cell activation. However, the reverse signaling pathway transduced by TRAIL is still not clear.It has been demonstrated that NF-kappaB was involved in CD28 costimulation signaling pathway, suggesting that NF-kappaB signaling pathway is important in costimulation of T cells. Recent studies have shown that the CARMA1, Bcl10, and MALT1 proteins are critical for the NF-kappaB signaling pathway to the TCR and CD28. Recently studies have confirmed that Akt plays a modulatory role and CARMA1 is required for Akt-mediated in NF-kappaB induction by TCR and CD28. In our previous study, we found that PI3K/Akt activity was enhanced after TRAIL-mediated T cell activation, suggest that PI3K/Akt signaling pathway is involved in TRAIL reverse signaling pathway. In this study, we use Western blotting to identify the role of NF-kappaB signaling pathway in TRAIL-induced costimulation of T cells. Our results showed that NF-kappaB activation and translocation into nucleus is enhanced in TRAIL-mediated T cell activation. In accordance with this observation is the concomitant enhanced degradation of IkappaB-alpha. Furthermore, TRAIL-mediated T cell proliferation and IL-2 production was significantly decreased by NF-kappaB inhibitor, indicating that NF-kappaB signaling pathway is involved in TRAIL-induced activation of T cells. Moreover, we directly induced PKC-theta phosphorylation and NF-kappaB translocation with DR4-Fc stimulation alone. These results indicated that TRAIL-reversed signaling in T cells transduce via enhancing NF-kappaB activation.
Subjects
訊息傳導路徑
signaling pathway
Type
other

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science