Role of decoy receptor 3 (DcR3) in T cell activation and apoptosis in Systemic Lupus Erythematosus (SLE)
Date Issued
2004
Date
2004
Author(s)
Chou, Shih-Yin
DOI
en-US
Abstract
Decoy receptor 3 (DcR3), a newly member of tumor necrosis factor receptor (TNFR) superfamily, is a receptor for Fas ligand (FasL), LIGHT and TL1A. The biological role of soluble DcR3 is not clear, while DcR3 mRNA has been reported over-expressed in patients with systemic lupus erythematosus (SLE). Here we demonstrated marked elevated serum DcR3 in patients with SLE compared with normal health controls, suggested that DcR3 may play a role in SLE. In order to clarify the possible mechanisms in the pathogenesis of SLE by DcR3, we study whether DcR3 could directly induce T cell activation and whether it could promote survival of activated T cells via inhibiting the activation induced cell death (AICD). Our results demonstrated that soluble DcR3-Fc enhanced human T cell proliferation and increased production of IL-2 and IFN-
Subjects
T 細胞
細胞凋亡
第三誘餌受體
紅斑性狼瘡
DcR3
SLE
T cell
apoptosis
SDGs
Type
other
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