Repository logo
  • English
  • 中文
Log In
Have you forgotten your password?
  1. Home
  2. College of Medicine / 醫學院
  3. Immunology / 免疫學研究所
  4. Distribution of TH17 cells in decidua from human early normal and anembryonic pregnancies
 
  • Details

Distribution of TH17 cells in decidua from human early normal and anembryonic pregnancies

Date Issued
2009
Date
2009
Author(s)
Chen, Kai-Chieh
URI
http://ntur.lib.ntu.edu.tw//handle/246246/181805
Abstract
Because half of the fetal genome derives from the father, the fetus is considered to be a foreigner by the maternal immune system. However concept is accepted without any rejection. This implies maintenance of normal pregnancy must be modified by several appropriate tolerogenic regulations in mammals. Leukocytes populations are an important component in human endometrium, and the populations increase at the first trimester of pregnancy compared with menstrual cycle. T cells in the human decidua are about 10% to 12% of total immune cells during pregnancy. CD4+ T helper cells are important players to modulate accurate immune responses. Recently a third subset of TH cells known as TH17 cells have been identified. Research in functions and regulatory roles of IL-17 and TH17 cells in human pregnancy is largely undetermined. As previous studies showed that many cytokines expressed in the maternal-fetal interface and exhibited regulatory roles in immunological tolerance, including IL-4, IL-1β, TNF-α, IFN-γ, TGF-β, IL-11, GM-CSF and IL-6. These cytokine milieu may support the differentiation of TH17 cells. IL-17 has been found in the maternal-fetal interface. Our previous results also showed CD8+ T cell-rich lymphoid aggregates are formed in decidua during early pregnancy. It suggests inflammation occurred in local environments and it’s known TH17 cells are one of the main mediator in inducing inflammation. Therefore, we propose that TH17 cells exist in human decidua after implantation. To investigate the TH17 population in decidua, we used immunostaining method to detect CD4+IL-17+ TH17 cells. Data indicated the phenotype of IL-17 producing cells are CD3+CD8- and CD3+CD4+ T cells. The percentage of CD4+IL-17+ TH17 cells in CD4+ T population are 41.5% in decidual tissues obtained from 11 cases of normal pregnancies and 19.5% in the decidua of anembryonic from 10 cases at 7-11 weeks of gestation. The TH17 cells are significantly higher in the decidua of normal pregnancies than that of anembryonic pregnancies. TGF-β is expressed exclusively on glandular epithelium, compared with IL-6 expression that is realatively scattered on stroma in decidua. TH17 cells appear as aggregates on stroma and the localization may be regulated by the existence of TGF-β and IL-6 in the decidua. The cytokine expression between normal and anembryonic pregnancy may be one of the reason causing the significant difference of TH17 population. TGF-β is comparably expressed between normal and anembryonic decidual tissues, however IL-6 positive staining seen to be more in the normal decidual tissues.The data showed TH17 cells proportion are higher in normal pregnancy and this could be the result of cytokine expresion diversity. Furthermore, this might indicate TH17 cells in decidua of human early pregnancy may have a unique role in mediating placenta development through the coordinated action of their effector cytokines.
Subjects
TH17 cell
IL-17
decidua
File(s)
Loading...
Thumbnail Image
Name

ntu-98-R96449011-1.pdf

Size

23.32 KB

Format

Adobe PDF

Checksum

(MD5):281d3355ad052ee8e3c268cf8f3fc2f3

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Open policy finder網站查詢,以確認出版單位之版權政策。
    Please use Open policy finder to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)

Built with DSpace-CRIS software - Extension maintained and optimized by 4Science