DC 欄位 | 值 | 語言 |
dc.contributor | 江伯倫 | zh-TW |
dc.contributor | 臺灣大學:免疫學研究所 | zh-TW |
dc.contributor.author | 李坤珀 | zh-TW |
dc.contributor.author | Li, Kun-Po | en |
dc.creator | 李坤珀 | zh-TW |
dc.creator | Li, Kun-Po | en |
dc.date | 2009 | en |
dc.date.accessioned | 2010-05-10T10:54:14Z | - |
dc.date.accessioned | 2018-07-09T01:39:22Z | - |
dc.date.available | 2010-05-10T10:54:14Z | - |
dc.date.available | 2018-07-09T01:39:22Z | - |
dc.date.issued | 2009 | - |
dc.identifier.other | U0001-2807200917593300 | en |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/181822 | - |
dc.description.abstract | B-1 cells are a class of atypical B lymphocytes distinguished from conventional B-2 cells. It has been reported that the B-1 cells may play some roles in innate immunity, autoimmune diseases, and leukemia. Since B-1 cells are one of the most important sources of IL-10, we hypothesize that the B-1 cells may suppress the T cells activity and induce the generation of Tr1 cells. The mouse peritoneal cavity cells were analyzed and the B-1 cells were purified for following experiments. These B-1 cells could spontaneously secreted IL-10 and up-regulated the IL-10 production after LPS stimulation. The B-1 cells would inhibit proliferation of T cells through soluble factors. However, the B-1 cells could not efficiently induce the generation of IL-10-producing Treg cells in our system. In the contrast, the B-2 cell-induced Treg cells, “TofB2” cells, showed suppressive ability, and they presented Foxp3-CD25+CD62L+ phenotype and expressed high level of IL-10 and IL-4. In conclusion, the B-1 cells inhibited proliferation of T cells through soluble factors, and the B-2 cells join the immune modulation through inducing Treg cells generation. In different mechanisms, both B cell populations play regulatory roles in immune response. The studies may provide potent clinical application in treatments for autoimmune diseases. | en |
dc.description.tableofcontents | 1. 摘要…………………………………………………………………………………i. Abstract……………………………………………………………………………ii. Contents…………………………………………………………………………iii. Contents of Figures………………………………………………………...…….iv. Introduction…………………………………..……………………………………1. Experimental Aims………………………………..………………………………9. Materials………………………………………………………………………….10. Methods…………………………………………………………………………..15. Results……………………………………………………………………………220. Discussion………………………………………………………………………...301. Figures……………………………………………………………………………392. References………………………………………………………………………63 | en |
dc.format | application/pdf | en |
dc.format.extent | 5224644 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | en | en |
dc.language.iso | en_US | - |
dc.subject | B-1淋巴球 | zh-TW |
dc.subject | B-2淋巴球 | zh-TW |
dc.subject | 調節性T細胞 | zh-TW |
dc.subject | 介白素-10 | zh-TW |
dc.subject | B-1 Lymphocytes | en |
dc.subject | B-2 Lymphocytes | en |
dc.subject | Regulatory T cells (Treg) | en |
dc.subject | IL-10 | en |
dc.title | 研究B-1淋巴球在免疫調節功能的機轉 | zh-TW |
dc.title | The Roles of B-1 Cells in Immune Modulation | en |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/181822/1/ntu-98-R96449005-1.pdf | - |
item.languageiso639-1 | en_US | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 免疫學研究所
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