Recruitment of SUMOylated and tyrosine-phospholated c-Maf to c-Maf mediated cytokine genes in Th17 cells
Date Issued
2012
Date
2012
Author(s)
Cheng, Wan-Chen
Abstract
c-Maf was discovered as a transcription factor of IL-4 to regulate Th2-specific Il4 gene expression. Previous studies in our lab has shown that post-transcriptional modifications, such as tyrosine-phosphorylation and SUMOylation, are important to regulate c-Maf function. Furthermore, SUMOylation attenuates c-Maf-dependent IL-4 expression. Whereas, the tyrosine-phospholated c-Maf enhances the IL-4 production. c-Maf mediates IL-21, IL-10 and IL-22 expression in Th cells. In this study, we domostrate that the phosphorylation of c-Maf enhances the IL-10 production in EL4 cells through increases the c-Maf DNA binding ability. In taddition, the IL-10 and IL-21 production are enhanced by phosphorylated c-Maf in Th17 cells.
Subjects
c-Maf
Type
thesis
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