Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas
Resource
Cancer Letters 201,97-106
Journal
Cancer Letters 201
Pages
97-106
Date Issued
2003
Date
2003
Author(s)
Chen, Hui-Chun
Chu, Ricky-Y.
Hsu, Ping-Ning
DOI
246246/2006111501222542
Abstract
Perturbation in E-cadherin expression leads to loss of cellular adhesion with possible consequence of cellular transformation
and tumor progression. The aims of this study were to determine E-cadherin expression in each subtype of gastric cancer
classified by different classification systems, and to investigate the role of E-cadherin in cell differentiation, cancer invasion and
metastasis. Expression of E-cadherin was analyzed in 84 patients with gastric adenocarcinoma by immunohistochemistry and
correlated with clinicopahotlogical parameters. Our results showed loss of E-cadherin expression in 0% (0/3), 20.0% (9/45),
48% (15/31), 100% (3/3) and 100% (2/2) of papillary, tubular, poorly differentiated, signet-ring cell, and mucinous
adenocarcinoma by Japanese histological classification. The reduction of E-cadherin expression was inversely correlated with
the grade of differentiation. According to the histological classification of Lauren and Ming, the frequency of lost E-cadherin
expression was higher in diffuse type (65%) and infiltrative type (64%) gastric cancer than in intestinal type (20%, P ,0:001
Þ and expanding type cancer (22%, P ,0:001
Þ
; respectively. The loss of E-cadherin expression was significantly associated with
tumor invasion
ð
P ,0:05
Þ
: Furthermore, there was a borderline association between the loss of E-cadherin expression and poor
survival
ð
P
¼
0:109
Þ
: These data demonstrated a striking correlation between E-cadherin expression and the differentiation of
gastric carcinoma. The loss of E-cadherin expression may contribute to gastric cancer invasion to adjacent organs.
Subjects
Gastric cancer
E-cadherin
Differentiation
Invasion
Prognosis
SDGs
Type
journal article
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