|Title:||Involvement of P38 Mitogen-Activated Protein Kinase in Different Stages of Thymocyte Development||Authors:||WU, CHIA-CHENG
|Keywords:||T-CELL ACTIVATION;MAP KINASE;POSITIVE SELECTION||Issue Date:||2003||Journal Volume:||v.101||Journal Issue:||n.3||Start page/Pages:||970-976||Source:||BLOOD||Abstract:||
Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)-activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal-regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p 38 MAPK impaired CD4(-)CD8(-) thymocyte development and T- cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that , in addition to early thymocyte development, p38 is involved in positive selection.
|Appears in Collections:||免疫學研究所|
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