https://scholars.lib.ntu.edu.tw/handle/123456789/160565
Title: | Involvement of P38 Mitogen-Activated Protein Kinase in Different Stages of Thymocyte Development | Authors: | WU, CHIA-CHENG LAI, MING-ZONG |
Keywords: | T-CELL ACTIVATION;MAP KINASE;POSITIVE SELECTION | Issue Date: | 2003 | Journal Volume: | v.101 | Journal Issue: | n.3 | Start page/Pages: | 970-976 | Source: | BLOOD | Abstract: | Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)-activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal-regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p 38 MAPK impaired CD4(-)CD8(-) thymocyte development and T- cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that , in addition to early thymocyte development, p38 is involved in positive selection. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/96915 |
Appears in Collections: | 免疫學研究所 |
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