https://scholars.lib.ntu.edu.tw/handle/123456789/160565
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 免疫學研究所 | en |
dc.contributor.author | WU, CHIA-CHENG | en |
dc.contributor.author | LAI, MING-ZONG | en |
dc.creator | 吳佳城;賴明宗 | zh-tw |
dc.creator | WU, CHIA-CHENG;LAI, MING-ZONG | en |
dc.date | 2003 | en |
dc.date.accessioned | 2009-01-16T02:41:53Z | - |
dc.date.accessioned | 2018-07-09T01:48:54Z | - |
dc.date.available | 2009-01-16T02:41:53Z | - |
dc.date.available | 2018-07-09T01:48:54Z | - |
dc.date.issued | 2003 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/96915 | - |
dc.description.abstract | Positive selection of thymocytes during T-cell development is mediated by T-cell receptor (TCR)-activated signals. For different mitogen-activated protein kinases (MAPKs) activated by TCR complex, a selective involvement of extracellular signal-regulated kinase, but not p38 MAPK, in positive selection has been suggested. Using transgenic mice with dominant-negative mutation of both MAP kinase kinase 3 (MMK3) and MKK6, we obtained mice with different extents of inhibition of p38 MAPK activation. Partial inhibition of p 38 MAPK impaired CD4(-)CD8(-) thymocyte development and T- cell proliferation, but not positive selection. Interference with thymocyte positive selection was observed in mice with effective suppression of p38 MAPK. Our results suggest that , in addition to early thymocyte development, p38 is involved in positive selection. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | BLOOD v.101 n.3 pp.970-976 | en |
dc.relation.ispartof | BLOOD | - |
dc.subject | T-CELL ACTIVATION | en |
dc.subject | MAP KINASE | en |
dc.subject | POSITIVE SELECTION | en |
dc.title | Involvement of P38 Mitogen-Activated Protein Kinase in Different Stages of Thymocyte Development | en |
dc.relation.pages | 970-976 | - |
dc.relation.journalvolume | v.101 | - |
dc.relation.journalissue | n.3 | - |
item.languageiso639-1 | en_US | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
顯示於: | 免疫學研究所 |
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