https://scholars.lib.ntu.edu.tw/handle/123456789/160735
標題: | Deltex1 Is a Target of the Transcription Factor Nfat That Promotes T Cell Anergy | 作者: | Hsiao, Huey-Wen Liu, Wen-Hsien Wang, Chen-Jhe Lo, Yu-Hsun Wu, Yung-Hsuan Jiang, Si-Tse Lai, Ming-Zong |
公開日期: | 2009 | 起(迄)頁: | 72-83 | 來源出版物: | Immunity | 摘要: | The molecular process underlying T cell anergy is incompletely understood . Deltex1 (DTX1) is a Notch target with unknown physiological function. Here we show that Dtx1 was a transcription target of nuclear factor of activated T cells (NFAT) and participated in T cell anergy. DTX1 protein was upregulated during T cell anergy, and transgenic expression of Dtx1 attenuated T cell activation. DTX1 inhibited T cell activation by both E3- dependent and E3- independent mechanisms. In addition, DTX1 suppressed T cell activation in the absence of its Notch-binding domain. Importantly, DTX1 regulated the expression of two anergy- associated molecules, growth arrest and DNA-damage-inducible 45 beta (Gadd45 beta) and Cbl-b. DTX1 interacted with early growth response 2 (Egr-2) for optimum expression of Cbl-b. Furthermore, deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation , and increased inflammation. DTX1 therefore represents a component downstream of calcium-NFAT signaling that regulates T cell anergy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/185910 | DOI: | 10.1016/j.immuni.2009.04.017 |
顯示於: | 免疫學研究所 |
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