https://scholars.lib.ntu.edu.tw/handle/123456789/160735
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 免疫學研究所 | en |
dc.contributor.author | Hsiao, Huey-Wen | en |
dc.contributor.author | Liu, Wen-Hsien | en |
dc.contributor.author | Wang, Chen-Jhe | en |
dc.contributor.author | Lo, Yu-Hsun | en |
dc.contributor.author | Wu, Yung-Hsuan | en |
dc.contributor.author | Jiang, Si-Tse | en |
dc.contributor.author | Lai, Ming-Zong | en |
dc.creator | 駱育壎;賴明宗 | zh-tw |
dc.creator | Hsiao, Huey-Wen; Liu, Wen-Hsien; Wang, Chen-Jhe; Lo, Yu-Hsun; Wu, Yung-Hsuan; Jiang, Si-Tse; Lai, Ming-Zong | en |
dc.date | 2009 | en |
dc.date.accessioned | 2010-06-23T06:16:22Z | - |
dc.date.accessioned | 2018-07-09T01:54:10Z | - |
dc.date.available | 2010-06-23T06:16:22Z | - |
dc.date.available | 2018-07-09T01:54:10Z | - |
dc.date.issued | 2009 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/185910 | - |
dc.description.abstract | The molecular process underlying T cell anergy is incompletely understood . Deltex1 (DTX1) is a Notch target with unknown physiological function. Here we show that Dtx1 was a transcription target of nuclear factor of activated T cells (NFAT) and participated in T cell anergy. DTX1 protein was upregulated during T cell anergy, and transgenic expression of Dtx1 attenuated T cell activation. DTX1 inhibited T cell activation by both E3- dependent and E3- independent mechanisms. In addition, DTX1 suppressed T cell activation in the absence of its Notch-binding domain. Importantly, DTX1 regulated the expression of two anergy- associated molecules, growth arrest and DNA-damage-inducible 45 beta (Gadd45 beta) and Cbl-b. DTX1 interacted with early growth response 2 (Egr-2) for optimum expression of Cbl-b. Furthermore, deficiency of DTX1 augmented T cell activation, conferred resistance to anergy induction, enhanced autoantibody generation , and increased inflammation. DTX1 therefore represents a component downstream of calcium-NFAT signaling that regulates T cell anergy. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | IMMUNITY v.31 n.1 pp.72-83 | en |
dc.relation.ispartof | Immunity | en_US |
dc.title | Deltex1 Is a Target of the Transcription Factor Nfat That Promotes T Cell Anergy | en |
dc.identifier.doi | 10.1016/j.immuni.2009.04.017 | - |
dc.relation.pages | 72-83 | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
item.fulltext | no fulltext | - |
顯示於: | 免疫學研究所 |
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