DC 欄位 | 值 | 語言 |
dc.contributor | 免疫學研究所 | en |
dc.contributor.author | Ramon Gimeno | en |
dc.contributor.author | Lee, Chien-kuo | en |
dc.contributor.author | Christian Schindler | en |
dc.contributor.author | David E. Levy | en |
dc.contributor.author | 李建國 | zh |
dc.creator | Ramon Gimeno | en |
dc.creator | Lee, Chien-kuo | en |
dc.creator | Christian Schindler | en |
dc.creator | David E. Levy | en |
dc.creator | 李建國 | zh |
dc.date | 2005-07 | - |
dc.date.accessioned | 2011-04-29T05:17:25Z | - |
dc.date.accessioned | 2018-07-09T01:57:00Z | - |
dc.date.available | 2011-04-29T05:17:25Z | - |
dc.date.available | 2018-07-09T01:57:00Z | - |
dc.date.issued | 2005-07 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/233065 | - |
dc.description.abstract | Alpha/beta interferon (IFN-{alpha}/ß) triggers
antiviral and antiproliferative responses in target cells
through modulation of gene expression. The JAK-STAT pathway
is the major mediator of these biological effects through
the activation of the transcription factors STAT1 and STAT2,
and gene ablation studies have demonstrated that both STAT1
and STAT2 are required for most antiviral responses induced
by IFN-{alpha}/ß. However, additional signaling
pathways are also activated by IFN. Here, we show that these
additional pathways provoke a proliferative response in
activated T lymphocytes. While activation of IFN-stimulated
gene factor 3 produces a dominant inhibitory signal capable
of overriding the mitogenic response, absence of either STAT
1 or STAT2 leads to a proliferative response to IFN. Growth
stimulation by IFN-{alpha}/ß is independent of other
STAT proteins, particularly of STAT3, since T lymphocytes
from STAT1-STAT3 double-knockout mice are growth stimulated
by IFN-{alpha}/ß treatment. IFN-{alpha}/ß can
cooperate with numerous T-cell mitogens, including
interleukin-2 (IL-2), IL-4, IL-7, and IL-12, and can
contribute to the rapid restoration of the thymus following
glucocorticoid-mediated ablation. These results underscore
the complexity of the cellular response to IFN and suggest
that the ultimate outcome of IFN action results from a
balance between growth-inhibitory and -stimulatory effects. | en |
dc.format.extent | 536576 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh_TW | en |
dc.language.iso | en_US | - |
dc.relation | MOLECULAR AND CELLULAR BIOLOGY, 25(13), 5456-5465 | en |
dc.relation.ispartof | MOLECULAR AND CELLULAR BIOLOGY | en_US |
dc.title | STAT1 AND STAT2 BUT NOT STAT3 ARBITRATE CONTRADICTORY GROWTH SIGNALS ELICITED BY IFNα/β IN T LYMPHOCYTES | en |
dc.relation.pages | 5456-5465 | - |
dc.relation.journalvolume | 25 | - |
dc.relation.journalissue | 13 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/233065/1/MCB 2005.pdf | - |
item.languageiso639-1 | en_US | - |
item.fulltext | with fulltext | - |
item.grantfulltext | open | - |
顯示於: | 免疫學研究所
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