https://scholars.lib.ntu.edu.tw/handle/123456789/160928
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 臺大醫學院-免疫學研究所; | - |
dc.contributor.author | Hsiao, Huey-Wen | en |
dc.contributor.author | Hsu, Tzu-Sheng | en |
dc.contributor.author | Liu, Wen-Hsien | en |
dc.contributor.author | Hsieh, Wan-Chen | en |
dc.contributor.author | Chou, Ting-Fang | en |
dc.contributor.author | Wu, Yu-Jung | en |
dc.contributor.author | Jiang, Si-Tse | en |
dc.contributor.author | Lai, Ming-Zong | en |
dc.creator | Hsiao, Huey-Wen;Hsu, Tzu-Sheng;Liu, Wen-Hsien;Hsieh, Wan-Chen;Chou, Ting-Fang;Wu, Yu-Jung;Jiang, Si-Tse;Lai, Ming-Zong | en |
dc.creator | 賴明宗 | zh-tw |
dc.date | 2015 | - |
dc.date.accessioned | 2017-05-25T05:36:43Z | - |
dc.date.accessioned | 2018-07-09T02:01:28Z | - |
dc.date.available | 2017-05-25T05:36:43Z | - |
dc.date.available | 2018-07-09T02:01:28Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/278954 | - |
dc.description.abstract | Application of regulatory Tcells (Tregs) in transplantation, autoimmunity and allergy has been extensively explored, but how Foxp3 and Treg stability is regulated in vivo is incompletely understood. Here, we identify a requirement for Deltex1 (DTX1), a contributor to T-cell anergy and Foxp3 protein level maintenance in vivo. Dtx1(-/-) Tregs are as effective as WT Tregs in the inhibition of CD4(+) CD25(-) T-cell activation in vitro. However, the suppressive ability of Dtx1(-/-) Tregs is greatly impaired in vivo. We find that Foxp3 expression is diminished when Dtx1(-/-) Tregs are co-transferred with effector Tcells in vivo. DTX1 promotes the degradation of HIF-1 alpha. Knockout of HIF-1 alpha restores the Foxp3 stability and rescues the defective suppressive activity in Dtx1(-/-) Treg cells in vivo. Our results suggest that DTX1 exerts another level of control on Treg stability in vivo by sustaining the expression of Foxp3 protein in Tregs. | - |
dc.language | en-us | - |
dc.relation | Nat. Commun., 6, | - |
dc.relation.ispartof | Nat. Commun. | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Deltex1 protein; hypoxia inducible factor 1alpha; suppressor factor; transcription factor FOXP3; ubiquitin protein ligase E3; unclassified drug; DNA binding protein; Dtx1 protein, mouse; forkhead transcription factor; Foxp3 protein, mouse; Hif1a protein, mouse; hypoxia inducible factor 1alpha; allergy; cell organelle; gene expression; protein; stabilization; animal cell; animal experiment; animal model; Article; CD4+ CD25+ T lymphocyte; cell specificity; clonal anergy; controlled study; female; gene deletion; gene inactivation; human; human cell; in vitro study; in vivo study; male; molecular stability; mouse; nonhuman; protein degradation; protein expression; protein function; protein protein interaction; protein stability; regulatory T lymphocyte; T lymphocyte activation; treatment failure; animal; C57BL mouse; hypersensitivity; immunology; inflammatory bowel disease; knockout mouse; lymphocyte activation; metabolism; physiology; regulatory T lymphocyte; Animals; DNA-Binding Proteins; Female; Forkhead Transcription Factors; Hypersensitivity; Hypoxia-Inducible Factor 1, alpha Subunit; Inflammatory Bowel Diseases; Lymphocyte Activation; Mice, Inbred C57BL; Mice, Knockout; T-Lymphocytes, Regulatory | - |
dc.title | Deltex1 antagonizes HIF-1 alpha and sustains the stability of regulatory T cells in vivo | - |
dc.identifier.doi | 10.1038/ncomms7353 | - |
dc.relation.pages | - | - |
dc.relation.journalissue | 6 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
顯示於: | 免疫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。