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  1. NTU Scholars
  2. 醫學院
  3. 腫瘤醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/161487
Title: JAK2 V617F Mutation in Adult Taiwanese Patients with Essential Thrombocythemia: More Prevalent in Old Patients and Correlated with Higher Hemoglobin Level and Higher Leukocyte Count
Authors: Lin, Huan-Chau
Chen, Caleb Gon-Shen
Chang, Ming-Chih
Wang, Wei-Ting
Kao, Chen Wei
Lo, An-Chi
Su, Nai-Wen
Chang, Yu-Cheng
Chiang, Yi-Hao
Chou, Kuei-Fang
Liao, Po-Nien
Cai, Guan-Jhe
Cheng, Hung-I
Lin, Johnson
Chang, Yi-Fang
Hsieh, Ruey-Kuen
Lim, Ken-Hong
Keywords: essential thrombocythemia;JAK2;mutation;prevalence
Issue Date: 2013
Start page/Pages: 40-44
Source: International Journal of Gerontology 
Abstract: 
Background: Essential thrombocythemia (ET) is classified as a chronic myeloproliferative neoplasm. JAK2 V617F mutation is found in about 50-60% patients with ET. We aim to determine the prevalence of JAK2 V617F mutation and its association with phenotype in adult Taiwanese patients with ET. ;Methods: In this combined retrospective and prospective study, adult ET patients, at least 18 years of age, were enrolled between November 2007 and September 2011. Genomic DNA was extracted from unsorted bone marrow and/or peripheral blood samples for the detection of JAK2 V617F mutation by allele-specific polymerase chain reaction. The clinical and laboratory characteristics of all patients at the time of diagnosis or referral were determined retrospectively by chart review. ;Results: A total of 82 patients were enrolled, and JAIC2 V617F mutation was detected in 55 patients (67.1%). JAK2 V617F mutation was significantly more prevalent in old patients (36.4% vs. 14.8%, p = 0.044), and associated with higher hemoglobin level (median 13.7 vs. 12.8 g/dL p = 0.012) and higher white blood cell count at diagnosis (12.1 x 10(3) vs. 8.8 x 10(3)/mu L p = 0.015). ET patients with the mutation also tend to have lower platelet count (median 902 x 10(3) vs. 1078 x 10(3)/mu L p = 0.051). In a binary logistic regression model, only higher hemoglobin concentration was significantly associated with JAK2 V617F mutational status (odds ratio 1.2 95% confidence interval 1.0-1.5; p = 0.047). ;Conclusion: JAK2 V617F mutation in Taiwanese adult patients with ET has a high prevalence of 67.1% and is associated with old age, higher hemoglobin level, and higher leukocyte count. Copyright (C) 2012, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved.
URI: http://ntur.lib.ntu.edu.tw//handle/246246/280046
DOI: 10.1016/j.ijge.2012.07.002
metadata.dc.subject.other: [SDGs]SDG3
genomic DNA; hemoglobin; Janus kinase 2; adult; aged; article; blood sampling; female; follow up; gene frequency; gene mutation; genetic association; hemoglobin blood level; hemoglobin determination; human; leukocyte count; major clinical study; male; medical record review; patient referral; phenotype; polymerase chain reaction; prevalence; priority journal; prospective study; retrospective study; senescence; Taiwan; thrombocyte count; thrombocythemia
Appears in Collections:腫瘤醫學研究所

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臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

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