https://scholars.lib.ntu.edu.tw/handle/123456789/161487
標題: | JAK2 V617F Mutation in Adult Taiwanese Patients with Essential Thrombocythemia: More Prevalent in Old Patients and Correlated with Higher Hemoglobin Level and Higher Leukocyte Count | 作者: | Lin, Huan-Chau Chen, Caleb Gon-Shen Chang, Ming-Chih Wang, Wei-Ting Kao, Chen Wei Lo, An-Chi Su, Nai-Wen Chang, Yu-Cheng Chiang, Yi-Hao Chou, Kuei-Fang Liao, Po-Nien Cai, Guan-Jhe Cheng, Hung-I Lin, Johnson Chang, Yi-Fang Hsieh, Ruey-Kuen Lim, Ken-Hong |
關鍵字: | essential thrombocythemia;JAK2;mutation;prevalence | 公開日期: | 2013 | 起(迄)頁: | 40-44 | 來源出版物: | International Journal of Gerontology | 摘要: | Background: Essential thrombocythemia (ET) is classified as a chronic myeloproliferative neoplasm. JAK2 V617F mutation is found in about 50-60% patients with ET. We aim to determine the prevalence of JAK2 V617F mutation and its association with phenotype in adult Taiwanese patients with ET. ;Methods: In this combined retrospective and prospective study, adult ET patients, at least 18 years of age, were enrolled between November 2007 and September 2011. Genomic DNA was extracted from unsorted bone marrow and/or peripheral blood samples for the detection of JAK2 V617F mutation by allele-specific polymerase chain reaction. The clinical and laboratory characteristics of all patients at the time of diagnosis or referral were determined retrospectively by chart review. ;Results: A total of 82 patients were enrolled, and JAIC2 V617F mutation was detected in 55 patients (67.1%). JAK2 V617F mutation was significantly more prevalent in old patients (36.4% vs. 14.8%, p = 0.044), and associated with higher hemoglobin level (median 13.7 vs. 12.8 g/dL p = 0.012) and higher white blood cell count at diagnosis (12.1 x 10(3) vs. 8.8 x 10(3)/mu L p = 0.015). ET patients with the mutation also tend to have lower platelet count (median 902 x 10(3) vs. 1078 x 10(3)/mu L p = 0.051). In a binary logistic regression model, only higher hemoglobin concentration was significantly associated with JAK2 V617F mutational status (odds ratio 1.2 95% confidence interval 1.0-1.5; p = 0.047). ;Conclusion: JAK2 V617F mutation in Taiwanese adult patients with ET has a high prevalence of 67.1% and is associated with old age, higher hemoglobin level, and higher leukocyte count. Copyright (C) 2012, Taiwan Society of Geriatric Emergency & Critical Care Medicine. Published by Elsevier Taiwan LLC. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/280046 | DOI: | 10.1016/j.ijge.2012.07.002 | SDG/關鍵字: | genomic DNA; hemoglobin; Janus kinase 2; adult; aged; article; blood sampling; female; follow up; gene frequency; gene mutation; genetic association; hemoglobin blood level; hemoglobin determination; human; leukocyte count; major clinical study; male; medical record review; patient referral; phenotype; polymerase chain reaction; prevalence; priority journal; prospective study; retrospective study; senescence; Taiwan; thrombocyte count; thrombocythemia |
顯示於: | 腫瘤醫學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。