https://scholars.lib.ntu.edu.tw/handle/123456789/161586
標題: | Intermediate Progenitors Facilitate Intracortical Progression of Thalamocortical Axons and Interneurons through CXCL12 Chemokine Signaling | 作者: | Abe, Philipp Molnar, Zoltan Tzeng, Yi-Shiuan DAR-MING LAI Arnold, Sebastian J. Stumm, Ralf |
關鍵字: | cortical development;CXCL12/CXCR4;intermediate/basal progenitors;interneuron;thalamocortical axons;thalamus | 公開日期: | 2015 | 起(迄)頁: | 13053-13063 | 來源出版物: | Journal of Neuroscience | 摘要: | Glutamatergic principal neurons, GABAergic interneurons and thalamocortical axons (TCAs) are essential elements of the cerebrocortical network. Principal neurons originate locally from radial glia and intermediate progenitors (IPCs), whereas interneurons and TCAs are of extrinsic origin. Little is known how the assembly of these elements is coordinated. C-X-C motif chemokine 12 (CXCL12), which is known to guide axons outside the neural tube and interneurons in the cortex, is expressed in the meninges and IPCs. Using mouse genetics, we dissected the influence of IPC-derived CXCL12 on TCAs and interneurons by showing that Cxcl12 ablation in IPCs, leaving meningeal Cxcl12 intact, attenuates intracortical TCA growth and disrupts tangential interneuron migration in the subventricular zone. In accordance with strong CXCR4 expression in the forming thalamus and TCAs, we identified a CXCR4-dependent growth-promoting effect of CXCL12 on TCAs in thalamus explants. Together, our findings indicate a cell-autonomous role of CXCR4 in promoting TCA growth. We propose that CXCL12 signals from IPCs link cortical neurogenesis to the progression of TCAs and interneurons spatially and temporally. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/280145 | DOI: | 10.1523/JNEUROSCI.1488-15.2015 |
顯示於: | 腫瘤醫學研究所 |
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