https://scholars.lib.ntu.edu.tw/handle/123456789/161823
標題: | Triflavin, an Arg-Gly-Asp-Containing Antiplatelet Peptide Inhibits Cell- Substratum Adhesion and Melanoma Cell-Induced Lung Colonization | 作者: | SHEU, JOEN-RONG LIN, CHAO-HSINE CHUNG, JIH-LUAN TENG, CHE-MING HUANG, TUR-FU |
關鍵字: | RGD-CONTAINING PEPTIDE,TUMOR CELL METASTASIS,EXTRACELLULAR;MATRIX | 公開日期: | 1992 | 卷: | v.83 | 期: | n.8 | 起(迄)頁: | 885-893 | 來源出版物: | JAPANESE JOURNAL OF CANCER RESEARCH | 摘要: | Triflavin, an Arg-Gly-Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. In this study, we show that triflavin (1-30 micrograms/mouse) inhibits B16-F10 melanoma cell-induced lung colonization in C57BL/6 mice in a dose-dependent manner . In vitro, triflavin dose-dependently inhibits adhesion of B16-F10 melanoma cells to extracellular matrices (ECMs; i.e. , fibronectin, fibrinogen, vitronectin, and collagen type I) . Triflavin is approximately 600-800 times more potent than GRGDS at inhibiting cell adhesion. In addition, triflavin dose -dependently inhibits B16-F10 cell-induced platelet aggregation. These results imply that the inhibitory effect of triflavin on the adhesion of tumor cells to ECMs (e.g., fibronectin, vitronectin and collagen type I) and/or tumor cell-induced platelet aggregation may be partially responsible for its antimetastatic activity in C57BL/6 mice. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/86136 |
顯示於: | 實驗動物中心 |
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