https://scholars.lib.ntu.edu.tw/handle/123456789/161834
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor | 動物中心 | en |
dc.contributor.author | WU, MING-FANG | en |
dc.contributor.author | HSU, YU-MING | en |
dc.contributor.author | CHUNG, JING-GUNG | en |
dc.contributor.author | LU, HSU-FENG | en |
dc.contributor.author | LIN, JING-PIN | en |
dc.contributor.author | TANG, NOU-YING | en |
dc.contributor.author | YEH, MING-YANG | en |
dc.creator | 吳銘芳;許祐銘;鍾景光;呂旭峰;林景彬;唐娜櫻;葉明陽 | zh-tw |
dc.creator | WU, MING-FANG;HSU, YU-MING;CHUNG, JING-GUNG;LU, HSU-FENG;LIN, JING-PIN;TANG, NOU-YING;YEH, MING-YANG | en |
dc.date | 2011 | en |
dc.date.accessioned | 2012-07-12T05:06:59Z | - |
dc.date.accessioned | 2018-07-09T04:27:19Z | - |
dc.date.available | 2012-07-12T05:06:59Z | - |
dc.date.available | 2018-07-09T04:27:19Z | - |
dc.date.issued | 2011 | - |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/241684 | - |
dc.description.abstract | Agaricus blazei Murill ABM is enriched with polysaccharides, lipids, vitamins, fibers and minerals. Many studies have shown that ABM possesses immune-enhancing and anti-tumor effects. However, little is known about its protective effects on liver function. We employed carbon tetrachloride CCl4 to induce hepatic fibrosis in a rat model to examine the protective effects of ABM on the liver in this study. The experiments included non- treatment control, CCl4-only control, and treatment with 200 mg and 2,000 mg of ABM extracts per kilogram rat weight. All groups other than the non- treatment control were treated with intraperitoneal injections of CCl4 twice a week. Experimental and control rats were tube-fed with experimental ABM extracts or double- distilled water, respectively, on the remaining four days each week. The whole experimental protocol lasted 8 weeks; blood and liver samples were collected for biochemical and tissue histochemical analysis. Plasma alanine aminotransferase and aspartate aminotransferase, and the activities of the anti-oxidative enzymes glutathione peroxidase, superoxide dismutase and catalase in the liver were measured. We found that high-dose ABM treatment reduced hepatic necrosis and fibrosis caused by CCl4 in comparison with the CCl4 control group. ALT and AST activities in the sera collected from ABM-treated rats were lower than those in the CCl4 control rats. These results suggested that ABM extract was capable of either enhancing liver recovering from CCl 4 damage or attenuating CCl4 toxicity. Results of anti-oxidative enzyme activity analysis showed no apparent differences among ABM-treated groups and CCl4 control groups , indicating that removal of free radicals does not explain the protective/recovery effects observed in this study. | en |
dc.language | en-us | en |
dc.language.iso | en_US | - |
dc.relation | IN VIVO v.25 n.1 pp.35-40 | en |
dc.relation.ispartof | IN | - |
dc.subject | ALT | en |
dc.subject | AST | en |
dc.subject | GSH | en |
dc.subject | catalase | en |
dc.subject | hepatic fibrosis | en |
dc.subject | CCl4 | en |
dc.subject | Agaricus blazei | en |
dc.subject | liver function | en |
dc.title | Agaricus Blazei Murill Extract Abrogates Ccl4-Induced Liver Injury in Rats | en |
dc.relation.pages | 35-40 | - |
dc.relation.journalvolume | VIVO | - |
dc.relation.journalissue | n.1 | - |
item.fulltext | no fulltext | - |
item.languageiso639-1 | en_US | - |
item.grantfulltext | none | - |
顯示於: | 實驗動物中心 |
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