|Title:||Blood profile of oral mucosal disease patients with both vitamin B-12 and iron deficiencies||Authors:||Chang, Julia Yu-Fong
|Keywords:||gastric parietal cell antibody;iron deficiency;macrocytosis;mean corpuscular volume;microcytosis;vitamin B-12 deficiency||Issue Date:||2015||Start page/Pages:||532-538||Source:||Journal of the Formosan Medical Association||Abstract:||
Background/Purpose: Vitamin B-12 and iron deficiencies lead to macrocytosis [mean corpuscular volume (MCV) >= 100 fL] and microcytosis (MCV < 80 fL), respectively. This study evaluated anemic status, MCV, serum homocysteine level, and serum gastric parietal cell antibody (GPCA) level in oral mucosal disease patients with both vitamin B-12 and iron deficiencies. ;Methods: The blood hemoglobin (Hb), iron, vitamin B-12, folic acid and homocysteine concentrations, MCV, and serum GPCA in 149 patients with both vitamin B-12 and iron deficiencies were measured and compared with the corresponding data in 149 age- and sex-matched healthy control subjects. ;Results: We found that 54 (36.2%), 16 (10.7%), 44 (29.5%), and 36 (24.2%) patients with both vitamin B-12 and iron deficiencies had Hb deficiency (men <13 g/dL, women <12 g/dL), folic acid deficiency (<= 6 mg/mL), abnormally high blood homocysteine level (>12.6 mu M), and serum GPCA positivity, respectively. Patients with both vitamin B-12 and iron deficiencies had a significantly higher frequency of Hb deficiency, abnormally elevated blood homocysteine level, and serum GPCA positivity than healthy control subjects (all p values < 0.001). Of 149 patients with both vitamin B-12 and iron deficiencies, 10 (6.7%) had high MCV (>= 100 fL), 108 (72.5%) had normal MCV (between 80 fL and 99 fL), and 31(20.8%) had low MCV (<80 fL). ;Conclusion: Approximately 73%, 30%, and 24% of patients with both vitamin B-12 and iron deficiencies are found to have normal MCV, abnormally high blood homocysteine level, and serum GPCA positivity, respectively. Copyright (C) 2015, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
|Appears in Collections:||臨床牙醫學研究所|
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