DC 欄位 | 值 | 語言 |
dc.contributor.author | 樓國隆 | zh_TW |
dc.contributor.author | Lou, Kuo-Long | en |
dc.creator | 樓國隆 | zh_TW |
dc.creator | Lou, Kuo-Long | en |
dc.date | 2001 | zh_TW |
dc.date.accessioned | 2006-07-26T03:03:59Z | - |
dc.date.accessioned | 2018-07-09T05:27:10Z | - |
dc.date.available | 2006-07-26T03:03:59Z | - |
dc.date.available | 2018-07-09T05:27:10Z | - |
dc.date.issued | 2001 | - |
dc.identifier | 892320B002234 | zh_TW |
dc.identifier.uri | http://ntur.lib.ntu.edu.tw//handle/246246/22658 | - |
dc.description.abstract | Rundown is a generally encountered problem
while recording KATP channel activity with inside-out
patches. No assigned structural fragment related to this
mechanism has yet been derived from any of the functional
analyses performed. Therefore, based on a combined
sequence and secondary structure alignment
against known crystal structure of segments from closely
related proteins, we propose here the three-dimensional
structural model of an intracellular C-terminal domain of
the Kir6.2 subunit in KATP channels. An E. coli CMPkinase
was suggested as template for the model building.
The subdomain arrangement of this novel kinase domain
and the structural correlation for UDP-docking are described.
With structural-functional interpretation, we
conclude that the reactivation of KATP channel rundown
by MgATP or UDP is very possibly regulated by this intracellular
kinase domain at the C-terminus of Kir6.2
subunit in KATP channels. | en |
dc.format | application/pdf | zh_TW |
dc.format.extent | 167732 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.language | zh-TW | zh_TW |
dc.language.iso | zh_TW | - |
dc.publisher | 臺北市:國立臺灣大學醫學院口腔生物科學研究所 | zh_TW |
dc.relation | J Mol Model 2001(7), 20-25 | en |
dc.relation.ispartof | J Mol Model 2001(7) | - |
dc.rights | 國立臺灣大學醫學院口腔生物科學研究所 | zh_TW |
dc.subject | Channel gating | en |
dc.subject | 3D homology modeling | en |
dc.subject | Kinase domain | en |
dc.subject | Kir6.2 | en |
dc.subject | Rundown reactivation | en |
dc.title | 哺乳動物腺核三磷酸感受性鉀離子通道晶體繞射結構性質之研究 | zh_TW |
dc.title | Involvement of a novel C-terminal kinase domain of Kir6.2
in the K-ATP channel rundown reactivation | en |
dc.type | journal article | en |
dc.relation.pages | 20-25 | - |
dc.identifier.uri.fulltext | http://ntur.lib.ntu.edu.tw/bitstream/246246/22658/1/892320B002234.pdf | - |
item.openairetype | journal article | - |
item.fulltext | with fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | open | - |
item.languageiso639-1 | zh_TW | - |
item.cerifentitytype | Publications | - |
顯示於: | 口腔生物科學研究所
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