https://scholars.lib.ntu.edu.tw/handle/123456789/163166
標題: | Relationship between Cardiovascular Outcomes and Proton Pump Inhibitor Use in Patients Receiving Dual Antiplatelet Therapy after Acute Coronary Syndrome | 作者: | HSIAO, SHARON FEI-YUAN WEN, YU-WEN HUANG, WENG- FOUNG CHEN, PEI-FEN TSAI, YI-WEN 蕭斐元 |
關鍵字: | clopidogrel;proton pump inhibitors;acute coronary syndrome;adverse cardiovascular outcomes | 公開日期: | 2011 | 卷: | v.20 | 期: | n.10 | 起(迄)頁: | 1043-1049 | 來源出版物: | PHARMACOEPIDEMIOLOGY AND DRUG SAFETY | 摘要: | Background There is conflicting evidence regarding the potential interaction between clopidogrel and proton pump inhibitors (PPIs), with observational studies suggesting an increased risk of adverse cardiovascular (CV) outcomes and clinical trials suggesting there is no such risk. Methods We conducted a retrospective cohort study to assess CV outcomes of 9753 patients taking dual antiplatelet therapy of aspirin plus clopidogrel with or without a PPI after hospitalization for acute coronary syndrome (ACS). Cox proportional hazards models were used to assess our primary endpoint of re-hospitalization for ACS in overall sample and a propensity score matching subsample. Results Among patients taking clopidogrel plus aspirin, concomitant use of PPI was not associated with the risk of re-hospitalization for ACS (adjusted hazard ratio [HR] 1 .12 [95% CI 0.72-1.73]) . The findings were consistent in the propensity score matching cohort (adjusted HR 0.82 [95% CI 0.43-1.54]). Compared with PPI nonusers, there is no significant association between each specific PPI users and the risk of re-hospitalization for ACS (adjusted HR; omeprazole 0.96 [95 % CI 0.35-2.66], pantoprazole 1.05 [95% CI 0.38-2.92], rabeprazole 0.60 [95% CI 0.17-2.17], esomeprazole 0.31 [95% CI 0.10-0.99] , and lansoprazole 0.82 [95% CI 0.32-2.07]). Conclusion In conclusion, this population-based cohort study found that concomitant use of clopidogrel and PPI in patients who received dual antiplatelet therapy after ACS was not associated with risk of ACS re-hospitalization. Together , our study and findings of recently published clinical trials suggest that there was no apparent CV interaction between clopidogrel and PPI in patients who received dual antiplatelet therapy. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/241885 |
顯示於: | 臨床藥學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。